{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:29:32Z","timestamp":1790378972053,"version":"4.1.0"},"reference-count":53,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p> Previous behavioral work, using a complex five-odorant identification task, demonstrated that olfactory marker protein (OMP) is critically involved in odor processing to the extent that its loss results in an alteration in odorant quality perception. Exactly how the lack of OMP exerts its influence on the perception of odorant quality is unknown. However, there is considerable neurophysiological evidence that different odorants produce different spatiotemporal patterns of neural activity at the level of the mucosa and that these patterns predict the psychophysically determined perceptual relationship among odorants. In this respect, OMP gene deletion is known to result in a constellation of physiologic defects (i.e., marked reduction in the electroolfactogram (EOG) and altered response and recovery kinetics) that would be expected to alter the odorant-induced spatiotemporal activity patterns that are characteristic of different odorants. This, in turn, would be expected to alter the spatiotemporal patterning of information that results from the mucosal projection onto the bulb, thereby changing odorant quality perception. To test the hypothesis that odorant-induced mucosal activity patterns are altered in mice lacking the gene for OMP, we optically recorded the fluorescent changes in response to odorant stimulation from both the septum and turbinates of both OMP-null and control mice using a voltage-sensitive dye (di-4-ANEPPS Molecular Probes, Eugene, OR) and a Dalsa 120 \u00d7 120, 12-bit CCD camera. To maintain continuity with the previous behavioral work, the odorants 2-propanol, citral, carvone, ethylacetoacetate, and propyl acetate were again used. Each odorant was randomly presented to each mucosal surface in a Latin-Square design. The results of this study demonstrated that, for both mouse strains, there do indeed exist different spatiotemporal activity patterns for different odorants. More importantly, however, these patterns significantly differed between OMP-null and control mice. That is, although the general regions of characteristic activity for different odorants were the same in both mouse strains, the patterns in the null animals were degraded relative to controls. These data suggest therefore that the alterations in mucosal activity may serve as the substrate for the behaviorally observed changes in odorant quality perception in the null mutant. <\/jats:p>","DOI":"10.1152\/jn.00806.2002","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:01:10Z","timestamp":1149055270000},"page":"3864-3873","source":"Crossref","is-referenced-by-count":30,"title":["OMP Gene Deletion Results in an Alteration in Odorant-Induced Mucosal Activity Patterns"],"prefix":"10.1152","volume":"90","author":[{"given":"S. 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Inherent spatial patterning of response to odorants in the salamander olfactory epithelium. In: Olfaction and Taste VII, edited by Van der Starr H. London: IRL, 1980, p. 163\u2013166."},{"key":"REF21","doi-asserted-by":"crossref","unstructured":"Kubik S, Strotmann J, Andreini L, and Breer H. Subfamily of olfactory receptors characterized by unique structural features and expression patterns. J Neurochem 69: 465\u2013475, 1997.","DOI":"10.1046\/j.1471-4159.1997.69020465.x"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.723"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-12-03837.1996"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(96)00046-9"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.1.150"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/6.4.249"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90562-6"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1982.48.2.584"},{"key":"REF29","unstructured":"Macrides F and Chorover SL. Olfactory bulb units: activity correlated with inhalation cycles and odor quality. Science 185: 84\u201387, 1972."},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80581-4"},{"key":"REF31","unstructured":"Margolis FL. A marker protein for the olfactory chemoreceptor neuron. In: Proteins of the Nervous System, edited by Bradshaw RA and Schneider D. New York: Raven, 1980, p. 59\u201384."},{"key":"REF32","unstructured":"Margolis FL, Baker H, Ivic L, Beinfeld M, Kream R, Firestein S, and Buiakova O. Influence of genetic background on phenotype of mice with an olfactory marker protein (OMP) deletion. Chem Senses 22: 741, 1997."},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81387-2"},{"key":"REF34","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1976.56.3.578"},{"key":"REF35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb49845.x"},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.19.8948"},{"key":"REF37","unstructured":"Ottoson D. Analysis of the electrical activity of the olfactory epithelium. Acta Physiol Scand Suppl 122: 1\u201383, 1956."},{"key":"REF38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04637.2001"},{"key":"REF39","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91322-6"},{"key":"REF40","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90145-G"},{"key":"REF41","unstructured":"Schiffman SS, Reynolds ML, and Young FW. Introduction to Multidimensional Scaling: Theory, Application, and Methods. New York: Academic, 1984."},{"key":"REF42","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10133"},{"key":"REF43","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.4.1950"},{"key":"REF44","unstructured":"Shepherd GM. Computational structure of the olfactory system. In: Olfaction: A Model System for Computational Neuroscience, edited by Davis JL and Eichenbaum H.Cambridge, MA: MIT Press, 1991, p. 3\u201342."},{"key":"REF45","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305773"},{"key":"REF46","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199212000-00005"},{"key":"REF47","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90029-9"},{"key":"REF48","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90422-M"},{"key":"REF49","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01275-M"},{"key":"REF50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.1.387"},{"key":"REF51","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199901180-00003"},{"key":"REF52","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.3.626"},{"key":"REF53","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90366-V"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00806.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:32:52Z","timestamp":1568003572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00806.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1152\/jn.00806.2002"],"URL":"https:\/\/doi.org\/10.1152\/jn.00806.2002","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}