{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:49:35Z","timestamp":1791348575567,"version":"4.3.1"},"reference-count":49,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p> Eye patching has revealed enhanced saccadic latencies or attention effects when orienting toward visual stimuli presented in the temporal versus nasal hemifields of humans. Such behavioral advantages have been tentatively proposed to reflect possible temporal\u2013nasal differences in the retinotectal pathway to the superior colliculus, rather than in the retinogeniculate pathway or visual cortex. However, this has not been directly tested with physiological measures in humans. Here, we examined responses of the human superior colliculus (SC) to contralateral visual field stimulation, using high spatial resolution fMRI, while manipulating which hemifield was stimulated and orthogonally which eye was patched. The SC responded more strongly to visual stimulation when eye-patching made this stimulation temporal rather than nasal. In contrast, the lateral geniculate nucleus (LGN) plus retinotopic cortical areas V1\u2013V3 did not show any temporal\u2013nasal differences and differed from the SC in this respect. These results provide the first direct physiological demonstration in humans that SC shows temporal\u2013nasal differences that LGN and early visual cortex apparently do not. This may represent a temporal hemifield bias in the strength of the retinotectal pathway, leading to a preference for the contralateral hemifield in the contralateral eye. <\/jats:p>","DOI":"10.1152\/jn.00835.2006","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T21:05:45Z","timestamp":1164834345000},"page":"1495-1502","source":"Crossref","is-referenced-by-count":72,"title":["Visual fMRI Responses in Human Superior Colliculus Show a Temporal\u2013Nasal Asymmetry That Is Absent in Lateral Geniculate and Visual Cortex"],"prefix":"10.1152","volume":"97","author":[{"given":"Richard","family":"Sylvester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Josephs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraint","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp010906"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1972.35.2.187"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200204160-00024"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0590"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Duvernoy HM. The Human Brain. New York: Springer-Verlag, 1999.","DOI":"10.1007\/978-3-7091-6792-2"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(98)00107-2"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902300106"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1972.35.4.542"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1038\/nature04169"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050264"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90567-3"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1038\/nn1169"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1990.2.2.81"},{"key":"R16","unstructured":"Josephs O, Houseman AM, Friston K, Turner R. Physiological noise modelling for multi-slice EPI fMRI using SPM. Proc Fifth Annu Meeting of ISMRM 1682, 1997."},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1989.1.4.291"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00553.2003"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007082"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1717-9"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(67)90004-2"},{"key":"R22","unstructured":"Laemle LK. A Golgy study of cellular morphology in the superficial layers of superior colliculus: man, Saimiri, and Macaca. J Hirnforsch 22: 253\u2013263, 1981."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-02-00486.1985"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(92)90033-F"},{"key":"R25","unstructured":"Lie C, Specht K, Ritzl A, Eickhoff S, Stephan KE, Meinke A, Ziles K, Fink GR. fMRI delineates asymmetrical representation of nasotemporal visual hemifields in human cortex\u2014a neural substrate for functional lateralization in the visual system. Proc 10th Meeting of OHBM 2004."},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1038\/35084005"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1038\/nn1269"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Moors J, Vendrik AJ. Responses of single units in the monkey superior colliculus to stationary flashing stimuli. Exp Brain Res 35: 333\u2013347, 1979.","DOI":"10.1007\/BF00236619"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408311101"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90007-1"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850402"},{"key":"R32","unstructured":"Porta JB. De Refractione Optices Parte: Libri Novem. Naples, Italy; Carlinum and Pacem, 1593."},{"key":"R34","unstructured":"Posner MI, Cohen Y. Attention and control of movements. In: Tutorials in Motor Behavior, edited by Stelmach GE, Region J. Amsterdam: North Holland Publ, 1980, p. 243\u2013258."},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1991.3.4.322"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218503"},{"key":"R37","unstructured":"Rothbart MK, Posner MI, Boylan A. Regulatory mechanisms in infant development. In: The Development of Attention: Research and Theory, edited by Enns JT. Amsterdam: Elsevier, 1990, p. 139\u2013160."},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1977.40.2.428"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00288.2005"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754376"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90059-0"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901960204"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01020-5"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2373-z"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1109\/42.650881"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050538"},{"key":"R47","unstructured":"Van Buren JM. The Retinal Ganglion Cell Layer. Springfield, IL: Charles C. Thomas, 1963."},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1162\/089892900562561"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00489-R"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90181-2"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00835.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:04:07Z","timestamp":1567991047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00835.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1152\/jn.00835.2006"],"URL":"https:\/\/doi.org\/10.1152\/jn.00835.2006","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}