{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:52:33Z","timestamp":1768618353790,"version":"3.49.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p> The transient potassium current ( I <jats:sub>A<\/jats:sub>) plays an important role in shaping the firing properties of pyloric neurons in the stomatogastric ganglion (STG) of the spiny lobster, Panulirus interruptus. The shal gene encodes I <jats:sub>A<\/jats:sub> in pyloric neurons. However, when we over-expressed the lobster Shal protein by shal RNA injection into the pyloric dilator (PD) neuron, the increased I <jats:sub>A<\/jats:sub> had somewhat different properties from the endogenous I <jats:sub>A<\/jats:sub>. The recently cloned K-channel interacting proteins (KChIPs) can modify vertebrate Kv4 channels in cloned cell lines. When we co-expressed hKChIP1 with lobster shal in Xenopusoocytes or lobster PD neurons, they produced A-currents resembling the endogenous I <jats:sub>A<\/jats:sub> in PD neurons; compared with currents evoked by shal alone, their voltage for half inactivation was depolarized, their kinetics of inactivation were slowed, and their recovery from inactivation was accelerated. We also co-expressed shal in PD neurons with lobster frequenin, which encodes a protein belonging to the same EF-hand family of Ca<jats:sup>2+<\/jats:sup> sensing proteins as hKChIP. Frequenin also restored most of properties of the shal-evoked currents to those of the endogenous A-currents, but the time course of recovery from inactivation was not corrected. These results suggest that lobster shal proteins normally interact with proteins in the KChIP\/frequenin family to produce the transient potassium current in pyloric neurons. <\/jats:p>","DOI":"10.1152\/jn.00837.2002","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:01:10Z","timestamp":1149055270000},"page":"1902-1909","source":"Crossref","is-referenced-by-count":13,"title":["KChIP1 and Frequenin Modify <i>shal<\/i>-Evoked Potassium Currents in Pyloric Neurons in the Lobster Stomatogastric Ganglion"],"prefix":"10.1152","volume":"89","author":[{"given":"Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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