{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:02:14Z","timestamp":1761663734149,"version":"3.37.3"},"reference-count":29,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health Office of the Director","award":["P51 OD011107"],"award-info":[{"award-number":["P51 OD011107"]}]},{"name":"NIH National Center for Advancing Translational Science (NCATS)","award":["UL1 TR001881"],"award-info":[{"award-number":["UL1 TR001881"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:p> The lower urinary tract (LUT) may be activated by spinal cord stimulation, but the physiological mapping characteristics of LUT activation with noninvasive transcutaneous spinal cord stimulation (TSCS) are not known. The effects of aging on the contractile properties of the detrusor are also not well understood. Therefore, TSCS was applied over the T<jats:sub>10<\/jats:sub>\/T<jats:sub>11<\/jats:sub> to L<jats:sub>6<\/jats:sub>\/L<jats:sub>7<\/jats:sub> spinous processes in adult ( n = 6) and aged ( n = 9) female rhesus macaques. A combination of urodynamic studies and electromyography recordings of the external urethral sphincter (EUS), external anal sphincter (EAS), and pelvic floor muscles was performed. Distinct functional maps were demonstrated for TSCS-evoked detrusor and urethral pressures and for the activation of the EUS, EAS, and pelvic floor muscles. The magnitude of responses for each peripheral target organ was dependent on TSCS location and strength. The strongest detrusor contraction was observed with TSCS at the L<jats:sub>1<\/jats:sub>\/L<jats:sub>2<\/jats:sub> site in adults and the L<jats:sub>3<\/jats:sub>\/L<jats:sub>4<\/jats:sub> site in aged subjects. TSCS-evoked bladder pressure at the L<jats:sub>1<\/jats:sub>\/L<jats:sub>2<\/jats:sub> site was significantly higher for the adults compared with the aged subjects ( P &lt; 0.05). Cumulative normalized TSCS-evoked pressures, calculated for five consecutive sites between the T<jats:sub>11<\/jats:sub>\/T<jats:sub>12<\/jats:sub> and L<jats:sub>3<\/jats:sub>\/L<jats:sub>4<\/jats:sub> levels, were significantly lower for aged compared with adult subjects ( P &lt; 0.05). The aged animals also showed a caudal shift for the TSCS site that generated the strongest detrusor contraction. We conclude that natural aging in rhesus macaques is associated with decreased detrusor contractility, a finding of significant translational research relevance as detrusor underactivity is a common occurrence with aging in humans. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Transcutaneous spinal cord stimulation (TSCS) was used to map lower urinary tract function in adult and aged rhesus macaques. Aging was associated with decreased peak pressure responses to TSCS, reduced cumulative normalized evoked bladder pressure responses, and a caudal shift for the site generating the strongest TSCS-induced detrusor contraction. We demonstrate the utility of TSCS as a new diagnostic tool for detrusor contractility assessments and conclude that aging is associated with decreased detrusor contractility in primates. <\/jats:p>","DOI":"10.1152\/jn.00840.2017","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T11:12:53Z","timestamp":1516187573000},"page":"1521-1527","source":"Crossref","is-referenced-by-count":16,"title":["Noninvasive neurophysiological mapping of the lower urinary tract in adult and aging rhesus macaques"],"prefix":"10.1152","volume":"119","author":[{"given":"Parag N.","family":"Gad","sequence":"first","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Kokikian","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari L.","family":"Christe","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Reggie","family":"Edgerton","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, California"},{"name":"Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, California"},{"name":"Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, California"},{"name":"Brain Research Institute, University of California, Los Angeles, California"},{"name":"Institut Guttmann, Hospital de Neurorehabilitaci\u00f3, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif A.","family":"Havton","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, California"},{"name":"Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00573.2014"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000381"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2401"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63247-0.00005-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815622974"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2401"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108184"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)52011-9"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00609.2014"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.2.335"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12011"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177243"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60547-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3109\/00365596809136982"},{"key":"B15","first-page":"11","volume":"15","author":"Miyazato M","year":"2013","journal-title":"Rev Urol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-013-0461-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00730.2011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902160105"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23495"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.036"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2005.10.004"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01128.2014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0057b.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815620628"},{"key":"B25","first-page":"88","volume":"51","author":"Summers L","year":"2012","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000821)424:2<233::AID-CNE4>3.0.CO;2-C"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.068536"},{"key":"B28","first-page":"246","volume":"28","author":"Walter JS","year":"2005","journal-title":"J Spinal Cord Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.5.1029"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00840.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T03:22:46Z","timestamp":1569381766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00840.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4,1]]}},"alternative-id":["10.1152\/jn.00840.2017"],"URL":"https:\/\/doi.org\/10.1152\/jn.00840.2017","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"type":"print","value":"0022-3077"},{"type":"electronic","value":"1522-1598"}],"subject":[],"published":{"date-parts":[[2018,4,1]]}}}