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Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and ankle-sprained rats. One day after ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single ankle stimulus modality. After ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after ankle sprain.<\/jats:p>","DOI":"10.1152\/jn.00852.2010","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T23:50:49Z","timestamp":1299714649000},"page":"2043-2049","source":"Crossref","is-referenced-by-count":9,"title":["Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle"],"prefix":"10.1152","volume":"105","author":[{"given":"Jae Hyo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas; and"},{"name":"Department of Meridian and Acupoint, College of Korean Oriental Medicine, Wonkwang University, Jeonbuk, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas; 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