{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:18:47Z","timestamp":1777421927733,"version":"3.51.4"},"reference-count":40,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Ja 240\/19"],"award-info":[{"award-number":["Ja 240\/19"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Germen Research Foundation","award":["Ja 240\/19"],"award-info":[{"award-number":["Ja 240\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p> Chronic injury of limb nerves leading to neuropathic pain affects deep somatic nerves. Here the functional properties of injured afferent fibers in the lateral gastrocnemius-soleus nerve were investigated 20 and 80 days after suturing the central stump of this muscle nerve to the distal stump of the sural nerve in anesthetized rats. Neurophysiological recordings were made from afferent axons identified in either the sciatic nerve (87 A-, 63 C-fibers) or the dorsal root L4\/L5 (52 A-, 26 C-fibers) by electrical stimulation of the injured nerve. About 70% of the functionally identified A-fibers had regenerated into skin by 80 days after nerve suture; the remaining A-fibers could be activated only from the injured nerve. In contrast, 93% of the functionally identified C-fibers could only be activated from the injured sural nerve after 80 days. Nearly half of the injured A- (45%) and C-fibers (44%) exhibited ongoing and\/or mechanically or thermally evoked activity. Because ~50% of the A- and C-fibers are somatomotor or sympathetic postganglionic axons, respectively, probably all injured muscle afferent A- and C-fibers developed ectopic activity. Ongoing activity was present in 17% of the A- and 46% of the C-fibers. Mechanosensitivity was present in most injured A- (99%) and C-fibers (85%), whereas thermosensitivity was more common in C-fibers (cold 46%, heat 47%) than in A-fibers (cold 18%, heat 12%). Practically all thermosensitive A-fibers and C-fibers were also mechanosensitive. Thus, unlike cutaneous axons, almost all A- and C-fibers afferents in injured muscle nerves demonstrate ectopic activity, even chronically after nerve injury. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY After chronic injury of a muscle nerve, allowing the nerve fibers to regenerate to the target tissue, 1) most afferent A-fibers are mechanosensitive and regenerate to the target tissue; 2) ectopic ongoing activity, cold sensitivity, and heat sensitivity significantly decrease with time after injury in A-afferents; 3) most afferent C-fibers do not regenerate to the target tissue; and 4) injured C-afferents maintain the patterns of ectopic discharge properties they already show soon after nerve injury. <\/jats:p>","DOI":"10.1152\/jn.00894.2017","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T10:58:24Z","timestamp":1519210704000},"page":"1889-1901","source":"Crossref","is-referenced-by-count":10,"title":["Mechano- and thermosensitivity of injured muscle afferents 20 to 80 days after nerve injury"],"prefix":"10.1152","volume":"119","author":[{"given":"Jan","family":"Tode","sequence":"first","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Kirillova-Woytke","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa H.","family":"Rausch","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Baron","sequence":"additional","affiliation":[{"name":"Division of Neurological Pain Research and Therapy, Department of Neurology, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfrid","family":"J\u00e4nig","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902750310"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28753-4_4561"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.2.743"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90111-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990913)412:1<186::AID-CNE14>3.0.CO;2-H"},{"key":"B6","first-page":"31","volume-title":"Wall and Melzack\u2019s Textbook of Pain","author":"Gold MS.","year":"2013","edition":"6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02974.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00203.2009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91091.2008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.09.004"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1943.sp004002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-33-10559.2003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1673-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902250213"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.057539"},{"key":"B16","series-title":"Control of Respiratory and Cardiovascular Systems","first-page":"381","volume-title":"Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems","author":"Kaufman MP","year":"1996"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00938.2010"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018497"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00173-5"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.66.4.1205"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01344.2007"},{"key":"B22","first-page":"283","volume-title":"Translational Pain Research: From Mouse to Man","author":"McCord JL","year":"2010"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90027-M"},{"key":"B24","first-page":"620","volume-title":"Wall and Melzack\u2019s Textbook of Pain","author":"Mense S","year":"2013","edition":"6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02742.2000"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.45.030183.001305"},{"key":"B27","series-title":"The Cardiovascular System. 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