{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:52:20Z","timestamp":1772913140049,"version":"3.50.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p> This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1 mA, 20 min \u00d7 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1, 3, and 5 for low- (30 Hz) and high-frequency (200 Hz) vibrations on the dominant and nondominant hands in 29 healthy adults (mean age\u2009=\u200922.86 yr; 15 men, 14 women). Only the dominant-hand 200-Hz VDT displayed statistically significant medium effect size improvement for mixed-model analysis of variance time-by-group interaction for active tDCS compared with sham. Post hoc contrasts were statistically significant for dominant-hand 200-Hz VDT on day 5 after tDCS compared with day 1 before tDCS, day 1 after tDCS, and day 3 before tDCS. There was a linear dose-response improvement with dominant-hand 200-Hz VDT mean difference decreasing from day 1 before tDCS peaking at \u221215.5% (SD =\u200934.9%) on day 5 after tDCS. Both groups showed learning effect trends over time for all VDT test conditions, but only the nondominant-hand 30-Hz VDT was statistically significant ( P = 0.03), although post hoc contrasts were nonsignificant after \u0160id\u00e1k adjustment. No adverse effects for tDCS were reported. In conclusion, anodal tDCS at 1 mA, 20 min \u00d7 5 days on the dominant sensory cortex can modulate a linear improvement of dominant-hand high-frequency VDT but not low-frequency or nondominant-hand VDT. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Repeated weak anodal transcranial direct current stimulation (1 mA, 20 min) on the dominant sensory cortex provides linear improvement in dominant-hand high-frequency vibration detection thresholds. No effects were observed for low-frequency or nondominant-hand vibration detection thresholds. <\/jats:p>","DOI":"10.1152\/jn.00926.2017","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T10:29:59Z","timestamp":1525429799000},"page":"610-616","source":"Crossref","is-referenced-by-count":4,"title":["Dose response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: a randomized sham-controlled trial"],"prefix":"10.1152","volume":"120","author":[{"given":"Brookes","family":"Folmli","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine, Bond University, Gold Coast, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Turman","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine, Bond University, Gold Coast, Queensland, 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