{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:54:02Z","timestamp":1790319242751,"version":"4.1.0"},"reference-count":70,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p> A high dose of sodium salicylate temporarily induces tinnitus, mild hearing loss, and possibly hyperacusis in humans and other animals. Salicylate has well-established effects on cochlear function, primarily resulting in the moderate reduction of auditory input to the brain. Despite decreased peripheral sensitivity and output, salicylate induces a paradoxical enhancement of the sound-evoked field potential at the level of the primary auditory cortex (A1). Previous electrophysiologic studies have begun to characterize changes in thalamorecipient layers of A1; however, A1 is a complex neural circuit with recurrent intracortical connections. To describe the effects of acute systemic salicylate treatment on both thalamic and intracortical sound-driven activity across layers of A1, we applied current-source density (CSD) analysis to field potentials sampled across cortical layers in the anesthetized rat. CSD maps were normally characterized by a large, short-latency, monosynaptic, thalamically driven sink in granular layers followed by a lower amplitude, longer latency, polysynaptic, intracortically driven sink in supragranular layers. Following systemic administration of salicylate, there was a near doubling of both granular and supragranular sink amplitudes at higher sound levels. The supragranular sink amplitude input\/output function changed from becoming asymptotic at approximately 50 dB to sharply nonasymptotic, often dominating the granular sink amplitude at higher sound levels. The supragranular sink also exhibited a significant decrease in peak latency, reflecting an acceleration of intracortical processing of the sound-evoked response. Additionally, multiunit (MU) activity was altered by salicylate; the normally onset\/sustained MU response type was transformed into a primarily onset response type in granular and infragranular layers. The results from CSD analysis indicate that salicylate significantly enhances sound-driven response via intracortical circuits. <\/jats:p>","DOI":"10.1152\/jn.00946.2011","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T05:54:58Z","timestamp":1334210098000},"page":"200-214","source":"Crossref","is-referenced-by-count":36,"title":["Intracortical circuits amplify sound-evoked activity in primary auditory cortex following systemic injection of salicylate in the rat"],"prefix":"10.1152","volume":"108","author":[{"given":"Daniel","family":"Stolzberg","sequence":"first","affiliation":[{"name":"Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chrostowski","sequence":"additional","affiliation":[{"name":"McMaster Integrative Neuroscience Discovery and Study, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Salvi","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Allman","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.5.1527"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199601)29:1<69::AID-DEV4>3.0.CO;2-K"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00027-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)00174-O"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510027565"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.2.425"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66046-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1044\/1059-0889(2008\/07-0025)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00008-2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00024-1"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nature09656"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0689-10.2010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229253"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001113)427:2<302::AID-CNE10>3.0.CO;2-J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00131-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00197-5"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.04.052"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00137-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00104-5"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200506210-00011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(04)00019-X"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895408"},{"key":"B25","first-page":"47","volume":"51","author":"Lockwood AH","year":"1999","journal-title":"Scand Audiol Suppl"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2006.08.001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0276-1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.02.028"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.04.073"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.10.003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.03.005"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.01.014"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902570108"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.1.37"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07039.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.12.063"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(96)00019-6"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01298.2006"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990215)404:3<332::AID-CNE5>3.0.CO;2-R"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181de4662"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902820311"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn259"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00182-5"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.06.022"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90406.2008"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005635"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.3.1322"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00518-X"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.02.015"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.05.027"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1321-07.2007"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.005"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.03.007"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.024"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1416-11.2011"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00240.2009"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1092-z"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199607080-00010"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000230504.25102.26"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1614-2"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.03.004"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200004070-00045"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-5-8"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.023"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902290404"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.06.014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1183"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.06.013"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107998108"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.073"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00946.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:45:26Z","timestamp":1568011526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00946.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7,1]]}},"alternative-id":["10.1152\/jn.00946.2011"],"URL":"https:\/\/doi.org\/10.1152\/jn.00946.2011","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}