{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:25:58Z","timestamp":1774506358306,"version":"3.50.1"},"reference-count":64,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092208\/Z\/10\/Z"],"award-info":[{"award-number":["092208\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det (Swedish Research Council)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:p> In the setting of injury, myelinated primary afferent fibers that normally signal light touch are thought to switch modality and instead signal pain. In the absence of injury, touch is perceived as more intense when firing rates of A\u03b2 afferents increase. However, it is not known if varying the firing rates of A\u03b2 afferents have any consequence to the perception of dynamic mechanical allodynia (DMA). We hypothesized that, in the setting of injury, the unpleasantness of DMA would be intensified as the firing rates of A\u03b2 afferents increase. Using a stimulus-response protocol established in normal skin, where an increase in brush velocity results in an increase of A\u03b2 afferent firing rates, we tested if brush velocity modulated the unpleasantness of capsaicin-induced DMA. We analyzed how changes in estimated low-threshold mechanoreceptor firing activity influenced perception and brain activity (functional MRI) of DMA. Brushing on normal skin was perceived as pleasant, but brushing on sensitized skin produced both painful and pleasant sensations. Surprisingly, there was an inverse relationship between A\u03b2 firing rates and unpleasantness such that brush stimuli that produced low firing rates were most painful and those that elicited high firing rates were rated as pleasant. Concurrently to this, we found increased cortical activity in response to low A\u03b2 firing rates in regions previously implicated in pain processing during brushing of sensitized skin, but not normal skin. We suggest that A\u03b2 signals do not merely switch modality to signal pain during injury. Instead, they exert a high- and low-frequency-dependent dual role in the injured state, with respectively both pleasant and unpleasant consequences. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY We suggest that A\u03b2 signals do not simply switch modality to signal pain during injury but play a frequency-dependent and dual role in the injured state with both pleasant and unpleasant consequences. These results provide a framework to resolve the apparent paradox of how touch can inhibit pain, as proposed by the Gate Control Theory and the existence of dynamic mechanical allodynia. <\/jats:p>","DOI":"10.1152\/jn.00977.2016","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T21:05:14Z","timestamp":1506546314000},"page":"3360-3369","source":"Crossref","is-referenced-by-count":20,"title":["Low-threshold mechanoreceptors play a frequency-dependent dual role in subjective ratings of mechanical allodynia"],"prefix":"10.1152","volume":"118","author":[{"given":"Line S.","family":"L\u00f6ken","sequence":"first","affiliation":[{"name":"Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Anatomy, University of California, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene 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