{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:41:43Z","timestamp":1792129303739,"version":"4.4.0"},"reference-count":73,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>\n                    Mammalian central pattern generators (CPGs) producing rhythmic movements exhibit extremely robust and flexible behavior. Network architectures that enable these features are not well understood. Here we studied organization of the brain stem respiratory CPG. By sequential rostral to caudal transections through the pontine-medullary respiratory network within an in situ perfused rat brain stem\u2013spinal cord preparation, we showed that network dynamics reorganized and new rhythmogenic mechanisms emerged. The normal three-phase respiratory rhythm transformed to a two-phase and then to a one-phase rhythm as the network was reduced. Expression of the three-phase rhythm required the presence of the pons, generation of the two-phase rhythm depended on the integrity of B\u00f6tzinger and pre-B\u00f6tzinger complexes and interactions between them, and the one-phase rhythm was generated within the pre-B\u00f6tzinger complex. Transformation from the three-phase to a two-phase pattern also occurred in intact preparations when chloride-mediated synaptic inhibition was reduced. In contrast to the three-phase and two-phase rhythms, the one-phase rhythm was abolished by blockade of persistent sodium current ( I\n                    <jats:sub>NaP<\/jats:sub>\n                    ). A model of the respiratory network was developed to reproduce and explain these observations. The model incorporated interacting populations of respiratory neurons within spatially organized brain stem compartments. Our simulations reproduced the respiratory patterns recorded from intact and sequentially reduced preparations. Our results suggest that the three-phase and two-phase rhythms involve inhibitory network interactions, whereas the one-phase rhythm depends on I\n                    <jats:sub>NaP<\/jats:sub>\n                    . We conclude that the respiratory network has rhythmogenic capabilities at multiple levels of network organization, allowing expression of motor patterns specific for various physiological and pathophysiological respiratory behaviors.\n                  <\/jats:p>","DOI":"10.1152\/jn.00985.2007","type":"journal-article","created":{"date-parts":[[2007,10,3]],"date-time":"2007-10-03T20:58:38Z","timestamp":1191445118000},"page":"3370-3387","source":"Crossref","is-referenced-by-count":438,"title":["Spatial and Functional Architecture of the Mammalian Brain Stem Respiratory Network: A Hierarchy of Three Oscillatory Mechanisms"],"prefix":"10.1152","volume":"98","author":[{"given":"J. C.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P. 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New York: Decker, 1995, p. 39\u201369."},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.119ad.x"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.11.008"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2415-05.2005"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00059-0"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90070-D"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.098848"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1007\/BF02423514"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.4.1772"},{"key":"R32","unstructured":"Koizumi H\n                      , Smith JC.\n                      Perturbation of respiratory pattern and rhythm in vitro by block of persistent sodium current (INaP).\n                      Soc Neurosci Abstr\n                      173.6\n                      : 2002."},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1038\/22540"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/75776"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(86)90007-9"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1923.sp002052"},{"key":"R37","unstructured":"MacGregor RI\n                      .\n                      Neural and Brain Modelling.\n                      New York: Academic Press, 1987."},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.3.687"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00092-8"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1038\/nn1357"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00008-8"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00091-3"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91194-8"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01478.2003"},{"key":"R45","doi-asserted-by":"crossref","unstructured":"Pace RW\n                      , Mackay DD, Feldman JL, Del Negro CA.\n                      Role of persistent sodium current in mouse pre-Botzinger neurons and respiratory rhythm generation.\n                      J Physiol\n                      2\n                      : 485\u2013496, 2007.","DOI":"10.1113\/jphysiol.2006.124602"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00147-6"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1038\/nn1650"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020682"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.01.011"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00908.2006"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.10.011"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.60.1.385"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1409"},{"key":"R54","unstructured":"Richter DW\n                      .\n                      Neural regulation of respiration: rhythmogenesis and afferent control. 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