{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:46:47Z","timestamp":1792129607506,"version":"4.4.0"},"reference-count":94,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>A fundamental question in systems biology addresses the issue of how flexibility is built into modulatory networks such that they can produce context-dependent responses. Here we examine flexibility in the serotonin (5-HT) response system that modulates the cycle frequency (cf) of a rhythmic motor output. We found that depending on the preparation, the same 5-min bath application of 5-HT to the pyloric network of the California spiny lobster, Panulirus interruptus, could produce a significant increase, decrease, or no change in steady-state cf relative to baseline. Interestingly, the mean circuit output was not significantly different among preparations prior to 5-HT application. We developed pharmacological tools to examine the preparation-to-preparation variability in the components of the 5-HT response system. We found that the 5-HT response system consisted of at least three separable components: a 5-HT<jats:sub>2\u03b2Pan<\/jats:sub>-like component mediated a rapid decrease followed by a sustained increase in cf; a 5-HT<jats:sub>1\u03b1Pan<\/jats:sub>-like component produced a small and usually gradual increase in cf; at least one other component associated with an unknown receptor mediated a sustained decrease in cf. The magnitude of the change in cf produced by each component was highly variable, so that when summed they could produce either a net increase, decrease, or no change in cf depending on the preparation. Overall, our research demonstrates that the balance of opposing components of the 5-HT response system determines the direction and magnitude of 5-HT\u2013induced change in steady-state cf relative to baseline.<\/jats:p>","DOI":"10.1152\/jn.00986.2007","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T01:11:44Z","timestamp":1207789904000},"page":"2844-2863","source":"Crossref","is-referenced-by-count":26,"title":["Serotonin Transduction Cascades Mediate Variable Changes in Pyloric Network Cycle Frequency in Response to the Same Modulatory Challenge"],"prefix":"10.1152","volume":"99","author":[{"given":"Nadja","family":"Spitzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady","family":"Cymbalyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Baro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/35082096"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00261.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00708.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-15-06712.1999"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-17-06597.1997"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4404-07.2007"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Beltz B, Eisen JS, Flamm R, Harris-Warrick RM, Hooper SL, Marder E.Serotonergic innervation and modulation of the stomatogastric ganglion of three decapod crustaceans (Panulirus interruptus,Homarus americanusandCancer irroratus).J Exp Biol109: 35\u201354, 1984.","DOI":"10.1242\/jeb.109.1.35"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.44.6.1089"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00397.2003"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.015222"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00453-8"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3679-04.2005"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.01.008"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00531-2"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.009"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20932"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0949-04.2004"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2006.08.018"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0062-04.2004"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5441"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-10-06205.1994"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1038\/378502a0"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-11-06544.1994"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903250410"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135751"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1122"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.10.004"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1159\/000067789"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-004-0533-4"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.5.847"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.5.866"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2078-04.2004"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Golowasch J, Abbott LF, Marder E.Activity-dependent regulation of potassium currents in an identified neuron of the stomatogastric ganglion of the crabCancer borealis. J Neurosci19: RC33, 1999.","DOI":"10.1523\/JNEUROSCI.19-20-j0004.1999"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-07-02113.1987"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09046.x"},{"key":"R36","unstructured":"Harris-Warrick RM, Marder E, Selverston AI, Moulins M.Editors.Dynamic Biological Networks: The Stomatogastric Nervous System.Cambridge, MA: MIT Press, 1992a."},{"key":"R37","unstructured":"Harris-Warrick RM, Nagy F, Nusbaum MP.Neuromodulation of stomatogastric networks by identified neurons and transmitters. In:Dynamic Biological Networks: The Stomatogastric Nervous System, edited by Harris-Warrick RM, Marder E, Selverston AI, Moulins M. Cambridge, MA: MIT Press, 1992b, p. 87\u2013137."},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1159\/000076158"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-07-02066.1990"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195397"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215119"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.1.437"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067020"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-05-01495.1990"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1274-07.2007"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.2.496"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00795.2006"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02523.2000"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.3.1188"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0482-04.2004"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00581-4"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.161516"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1949"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1982.48.6.1416"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00523.2002"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07331.2001"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-04803.2003"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(01)00022-3"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1162\/neco.2007.19.8.1985"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1038\/417343a"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00423.2005"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.6.2957"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.06.061"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1038\/nn1352"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08378.2001"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.130864"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0315-07.2007"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00772.2006"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05021.x"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04012.x"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1038\/nn1639"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705827104"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-005-3154-8"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(76)90008-3"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20092"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20456"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.012450"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05744.x"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04520.x"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06752.2000"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03894.x"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00764.2005"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02212.1998"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00320-2"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1038\/344866a0"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00704.2002"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8940"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10183.x"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1840-04.2004"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-10-04185.2002"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-02-00697.1997"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.03.003"},{"key":"R94","doi-asserted-by":"crossref","unstructured":"Zhang B, Harris-Warrick RM.Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network.J Exp Biol190: 55\u201377, 1994.","DOI":"10.1242\/jeb.190.1.55"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.5.1929"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00986.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T15:54:08Z","timestamp":1631030048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00986.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1152\/jn.00986.2007"],"URL":"https:\/\/doi.org\/10.1152\/jn.00986.2007","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}