{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:53:20Z","timestamp":1761580400842},"reference-count":57,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p> In the appendicular skeleton, substantial evidence demonstrates that somatosensory input from deep tissues including limb muscles and joints elicits somatosympathetic reflexes. Much less is known about the presence and organization of these reflexes from the axial skeleton. We determined if mechanical loading of the lumbar spine and lumbar paraspinal muscle irritation reflexively affects postganglionic sympathetic nerve discharge (SND) to the spleen and kidney. In 27 \u03b1-chloralose-anesthetized cats, the L<jats:sub>2\u20134<\/jats:sub> multifidus muscles were injected with the inflammatory irritant mustard oil (20%, 60 \u03bcl total) and a vertebral load (100% body weight) was applied dorsal-ventral at the L<jats:sub>3<\/jats:sub> spinous process. Mustard oil injection alone without vertebral loading ( n = 7) increased mean splenic SND (60%), renal SND (30%), and heart rate (HR; 52 bpm). Mustard oil injection accompanied by the vertebral load ( n = 7) increased mean splenic SND (55%), renal SND (16%), and HR (27 bpm). Blood pressure changes were biphasic and could not account for these changes. When the vertebral load accompanied mustard oil, the increases in splenic SND, renal SND, and HR remained elevated in a pattern significantly different from when the vertebral load was absent. Vehicle injection combined with the mechanical load ( n = 3) did not change any of the autonomic responses. Similarly, mustard oil injection combined with a mechanical load did not change these responses when either the medial branches of the dorsal rami from T<jats:sub>11<\/jats:sub>\u2013L<jats:sub>5<\/jats:sub> had been cut ( n = 4) or when the spinal cord had been transected between the second and third cervical vertebrae ( n = 6). The results indicate that inflammatory stimulation of multifidus muscle in the low back evokes a somatosympathetic reflex integrated supraspinally in the upper cervical spinal cord or higher. The reflex's afferent arm travels in the medial branch of the dorsal ramus, and its efferent arm can affect sympathetic outflow to the spleen and the kidney as well as HR and BP. A static mechanical load applied to the lumbar spine accompanying the inflammatory stimulus appears to sustain the inflammatory-induced reflex activity. <\/jats:p>","DOI":"10.1152\/jn.00999.2002","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:01:10Z","timestamp":1149055270000},"page":"2548-2559","source":"Crossref","is-referenced-by-count":7,"title":["Somatosympathetic Reflexes From the Low Back in the Anesthetized Cat"],"prefix":"10.1152","volume":"90","author":[{"given":"Y. M.","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Iowa Spine Research Center, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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The lumbosacral dorsal rami of the cat. J Anat 122: 653\u2013662, 1976."},{"key":"REF5","unstructured":"Bogduk N. The dorsal lumbar muscles of the cat. Acta Anz Jena 148: 55\u201367, 1980."},{"key":"REF6","unstructured":"Budgell B, Hotta H, and Sato A. Spinovisceral reflexes evoked by noxious and innocuous stimulation of the lumbar spine. J Neuromusculoskel Sys 3: 122\u2013130, 1995."},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(97)01173-5"},{"key":"REF8","unstructured":"Cavanaugh JM. Innervation of the lumbosacral spine. In: Managing Low Back Pain, edited by Kirkaldy-Willis WH Jr. and Bernard TN. New York: Churchill Livingstone, 1999, p. 39\u201364."},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100070310"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1038\/325151a0"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009498"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903310407"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1007\/BF01828841"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200006150-00009"},{"key":"REF15","doi-asserted-by":"crossref","unstructured":"Gelsema AJ, Bouman LN, and Karemaker JM. Short-latency tachycardia evoked by stimulation of muscle and cutaneous afferents. 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Reflexes controlling circulation, ventilatory and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: American Physiological Society, 1996, p. 381\u2013447."},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.1.105"},{"key":"REF25","unstructured":"Koepke JP and DiBona GF. Functions of the renal nerves. Physiologist 28: 47\u201352, 1985."},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092060109"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90182-1"},{"key":"REF28","doi-asserted-by":"crossref","unstructured":"Matsukawa K, Wall PT, Wilson LB, and Mitchell JH. Reflex responses of renal nerve activity during isometric muscle contraction in cats. Am J Physiol 259: H1380\u2013H1388, 1990.","DOI":"10.1152\/ajpheart.1990.259.5.H1380"},{"key":"REF29","doi-asserted-by":"crossref","unstructured":"Matsukawa K, Wall PT, Wilson LB, and Mitchell JH. Neurally mediated renal vasocontriction during isometric muscle contraction in cats. Am J Physiol 262: H833\u2013H838, 1992.","DOI":"10.1152\/ajpheart.1992.262.3.H833"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009887"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019017"},{"key":"REF32","unstructured":"Mense S and Simons DG. Muscle Pain. Philadelphia, PA: Lippincott Williams and Wilkins, 2001."},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014857"},{"key":"REF34","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(94)90058-2"},{"key":"atypb1","unstructured":"Ozaktay AC, Yamashita T, Cavanaugh JM, and King AI. Fine nerve fibers and endings in the fibrous capsule of the lumbar facet joint. Orthopedic Research Society 37th Annual Meeting: 353\u2013353, 1991. (Abstract)."},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006486"},{"key":"REF37","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00060-6"},{"key":"REF38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.2.753"},{"key":"REF39","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199511001-00002"},{"key":"REF40","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199508150-00013"},{"key":"REF41","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90350-1"},{"key":"REF42","unstructured":"Sato A and Swenson RS. Sympathetic nervous system response to mechanical stress of the spinal column in rats. J Manipulative Physiol Ther 7: 141\u2013147, 1984."},{"key":"REF43","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90167-2"},{"key":"REF44","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(85)90036-0"},{"key":"REF45","unstructured":"Schaible H-G and Schmidt RF. Neurobiology of articular nociceptors. In: Neurobiology of Nociceptors, edited by Belmonte C and Cervero F. New York: Oxford, 1996, p. 202\u2013219."},{"key":"REF46","unstructured":"Schultz A, Carter D, Grood E, King A, and Panjabi M. Posterior Support Structures - Part B, Basic Science Perspectives. In: New Perspectives on Low Back Pain, edited by Frymoyer JW and Gordon SL. Park Ridge, IL: American Academy of Orthopaedic Surgeons, 1989, p. 249\u2013275."},{"key":"REF47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.3.592"},{"key":"REF48","unstructured":"Videman T and Battie MC. A critical review of the epidemiology of idiopathic low back pain. In: Low Back Pain, edited by Weinstein JN and Gordon SL. Rosemont, IL: American Academy of Orthopaedic Surgeons, 1996, p. 317\u2013332."},{"key":"REF49","doi-asserted-by":"crossref","unstructured":"Vissing J, Iwamoto GA, Fuchs IE, Galbo H, and Mitchell JH. Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents. Am J Physiol 266: R824\u2013R830, 1994.","DOI":"10.1152\/ajpregu.1994.266.3.R824"},{"key":"REF50","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90044-C"},{"key":"REF51","doi-asserted-by":"crossref","unstructured":"Weaver LC, Fry HK, and Meckler RL. Differential renal and splenic nerve responses to vagal and spinal afferent inputs. Am J Physiol 246: R78\u2013R87, 1984.","DOI":"10.1152\/ajpregu.1984.246.1.R78"},{"key":"REF52","unstructured":"Webb-Peploe MM. The isovolumetric spleen: index of reflex changes in splanchnic vascular capacity. Am J Physiol 216: 407\u2013413, 1969."},{"key":"REF53","unstructured":"White AA and Panjabi MM. Clinical Biomechanics of the Spine. 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