{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:20:16Z","timestamp":1788542416832,"version":"build-2803163510"},"reference-count":41,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> A previous study identified neuronal activity in area 5 of the monkey posterior parietal cortex that reflects the numerosity of a series of self-performed actions. It is not known, however, whether area 5 is crucially involved in the selection of an action based on numerical information or, instead, merely reflects numerosity-related signals that originate in other brain regions. We transiently and focally inactivated area 5 to test its functional contributions to numerosity-based action selection. Two monkeys were trained to either push or turn a handle in response to a visual trigger signal. The selection of the action was solely based on numerical information from a series of actions performed by the monkey: select A five times, select B five times, and then return to A in a cyclical fashion. When muscimol was applied to a portion of area 5 in which the activity in the numerosity-selective cells was recorded, the error rate in the selection task increased significantly. This transient neural inactivation also caused omission errors that were not observed before the muscimol injection. A control task showed that the errors were not caused by motor deficits or impaired ability to select between two possible actions. Our results indicate that area 5 is crucial for selecting actions on the basis of numerical information about a series of actions performed by the tested individual. <\/jats:p>","DOI":"10.1152\/jn.01014.2009","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T03:16:08Z","timestamp":1274930168000},"page":"902-910","source":"Crossref","is-referenced-by-count":35,"title":["Deficits in Action Selection Based on Numerical Information After Inactivation of the Posterior Parietal Cortex in Monkeys"],"prefix":"10.1152","volume":"104","author":[{"given":"Hiromasa","family":"Sawamura","sequence":"first","affiliation":[{"name":"Department of Physiology, Tohoku University School of Medicine, Sendai;"},{"name":"Department of Ophthalmology, Tokyo University School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisetsu","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tohoku University 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