{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:34:56Z","timestamp":1789407296976,"version":"build-2803163510"},"reference-count":51,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>Interplay between posterior parietal cortex (PPC) and ipsilateral primary motor cortex (M1) is crucial during execution of movements. The purpose of the study was to determine whether functional PPC\u2013M1 connectivity in humans can be modulated by sensorimotor training. Seventeen participants performed a sensorimotor training task that involved tapping the index finger in synchrony to a rhythmic sequence. To explore differences in training modality, one group ( n = 8) learned by visual and the other ( n = 9) by auditory stimuli. Transcranial magnetic stimulation (TMS) was used to assess PPC\u2013M1 connectivity before and after training, whereas electroencephalography (EEG) was used to assess PPC\u2013M1 connectivity during training. Facilitation from PPC to M1 was quantified using paired-pulse TMS at conditioning-test intervals of 2, 4, 6, and 8 ms by measuring motor-evoked potentials (MEPs). TMS was applied at baseline and at four time points (0, 30, 60, and 180 min) after training. For EEG, task-related power and coherence were calculated for early and late training phases. The conditioned MEP was facilitated at a 2-ms conditioning-test interval before training. However, facilitation was abolished immediately following training, but returned to baseline at subsequent time points. Regional EEG activity and interregional connectivity between PPC and M1 showed an initial increase during early training followed by a significant decrease in the late phases. The findings indicate that parietal\u2013motor interactions are activated during early sensorimotor training when sensory information has to be integrated into a coherent movement plan. Once the sequence is encoded and movements become automatized, PPC\u2013M1 connectivity returns to baseline.<\/jats:p>","DOI":"10.1152\/jn.01049.2011","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T23:21:11Z","timestamp":1332458471000},"page":"3190-3199","source":"Crossref","is-referenced-by-count":50,"title":["Timing-dependent modulation of the posterior parietal cortex\u2013primary motor cortex pathway by sensorimotor training"],"prefix":"10.1152","volume":"107","author":[{"given":"Anke","family":"Karabanov","sequence":"first","affiliation":[{"name":"Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"},{"name":"the 4Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyun","family":"Jin","sequence":"additional","affiliation":[{"name":"Human Motor Control 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