{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:50Z","timestamp":1791877430758,"version":"4.3.4"},"reference-count":61,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>Neuronal excitability has a large impact on network behavior, and plasticity in intrinsic excitability could serve as an important information storage mechanism. Here we ask whether postsynaptic excitability of layer V pyramidal neurons from primary visual cortex can be rapidly regulated by activity. Whole cell current-clamp recordings were obtained from visual cortical slices, and intrinsic excitability was measured by recording the firing response to small depolarizing test pulses. Inducing neurons to fire at high-frequency (30\u201340 Hz) in bursts for 5 min in the presence of synaptic blockers increased the firing rate evoked by the test pulse. This long-term potentiation of intrinsic excitability (LTP-IE) lasted for as long as we held the recording (&gt;60 min). LTP-IE was accompanied by a leftward shift in the entire frequency versus current ( F-I) curve and a decrease in threshold current and voltage. Passive neuronal properties were unaffected by the induction protocol, indicating that LTP-IE occurred through modification in voltage-gated conductances. Reducing extracellular calcium during the induction protocol, or buffering intracellular calcium with bis-( o-aminophenoxy)- N,N,N\u2032,N\u2032-tetraacetic acid, prevented LTP-IE. Finally, blocking protein kinase A (PKA) activation prevented, whereas pharmacological activation of PKA both mimicked and occluded, LTP-IE. This suggests that LTP-IE occurs through postsynaptic calcium influx and subsequent activation of PKA. Activity-dependent plasticity in intrinsic excitability could greatly expand the computational power of individual neurons.<\/jats:p>","DOI":"10.1152\/jn.01059.2003","type":"journal-article","created":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T01:48:53Z","timestamp":1077587333000},"page":"341-348","source":"Crossref","is-referenced-by-count":130,"title":["Long-Term Potentiation of Intrinsic Excitability in LV Visual Cortical Neurons"],"prefix":"10.1152","volume":"92","author":[{"given":"Robert H.","family":"Cudmore","sequence":"first","affiliation":[{"name":"Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina G.","family":"Turrigiano","sequence":"additional","affiliation":[{"name":"Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/81453"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016875"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00527-0"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/72049"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00674-8"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093258"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05208.2000"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13445"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00593.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00611.x"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06553.2001"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010273"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90018-7"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229331"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, and Hidaka H.Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.J Biol Chem265: 5267\u20135272, 1990.","DOI":"10.1016\/S0021-9258(19)34116-X"},{"key":"R15A","doi-asserted-by":"publisher","DOI":"10.1101\/lm.64103"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222546399"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Desai NS, Rutherford LC, and Turrigiano GG.BDNF regulates the intrinsic excitability of cortical neurons.Learn Mem6: 284\u2013291, 1999a.","DOI":"10.1038\/9165"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1038\/9165"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-02022.2000"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1038\/79838"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-j0004.1999"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1162\/089976699300016359"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90337-Q"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90008-5"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1021\/bi00316a032"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03521.1998"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2473"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)90028-4"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00563-5"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00621.x"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1038\/nrn753"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5435.1870"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1126\/science.2549638"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.21.1.25"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10185"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.213"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050311"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05536.1996"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00641-X"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1038\/72082"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01177.2002"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02699.x"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00149.x"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.5.2358"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00542-6"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00821.2001"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10238.2003"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00353-5"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.1"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03639.2003"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02212.1998"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.1836"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-13-04878.2000"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01341-1"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178157"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03640.1995"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1038\/36103"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1126\/science.7916482"},{"key":"R58A","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1248"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00571.x"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.01059.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T21:23:18Z","timestamp":1623705798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.01059.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1152\/jn.01059.2003"],"URL":"https:\/\/doi.org\/10.1152\/jn.01059.2003","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}