{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:55:43Z","timestamp":1791194143508,"version":"4.1.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:p>\n                    Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1\/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC\n                    <jats:sub>50<\/jats:sub>\n                    of \u223c10 \u03bcM and is fully occluded by the P\/Q type calcium channel blocker \u03c9-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.\n                  <\/jats:p>","DOI":"10.1152\/jn.01066.2011","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T22:21:53Z","timestamp":1325110913000},"page":"1571-1575","source":"Crossref","is-referenced-by-count":13,"title":["Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P\/Q type calcium channels"],"prefix":"10.1152","volume":"107","author":[{"given":"Andrew J.","family":"Delaney","sequence":"first","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Power","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sah","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2155-07.2007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00846-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00511-0"},{"key":"B4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/138161280504230110102541","volume":"5","author":"Chenard BL","year":"1999","journal-title":"Current Pharma Design"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17017.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(97)78062-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00215-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00118.2003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.022"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008367"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nn1450"},{"key":"B12","first-page":"112","volume":"292","author":"Honda H","year":"1988","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"B13","first-page":"155","volume":"32","author":"Honda H","year":"1989","journal-title":"Proc West Pharmacol Soc"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature02194"},{"key":"B15","volume-title":"Nerve Muscle and Synapse","author":"Katz B","year":"1966"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1080108"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06876.2003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00528.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.012"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00030-A"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/355827a0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90210-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.08.011"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2009"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-05955.2002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.182600"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-02849.1998"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.10.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06889.2001"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/368144a0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301316"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1101\/lm.798908"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.2.930"},{"key":"B35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0026-895X(25)13275-6","volume":"44","author":"Williams K","year":"1993","journal-title":"Mol Pharmacol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.046"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.12"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.05.030"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.000305"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.01066.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T21:07:40Z","timestamp":1742159260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.01066.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3,15]]}},"alternative-id":["10.1152\/jn.01066.2011"],"URL":"https:\/\/doi.org\/10.1152\/jn.01066.2011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13843958.15282058","asserted-by":"object"}]},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}