{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:58:15Z","timestamp":1788047895345,"version":"build-2784847793"},"reference-count":46,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health (NIMH)","doi-asserted-by":"publisher","award":["MH051393"],"award-info":[{"award-number":["MH051393"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:p> When a behavior is repeated performance often improves, i.e., repetition priming occurs. Although repetition priming is ubiquitous, mediating mechanisms are poorly understood. We address this issue in the feeding network of Aplysia. Similar to the priming observed elsewhere, priming in Aplysia is stimulus specific, i.e., it can be either \u201cingestive\u201d or \u201cegestive.\u201d Previous studies demonstrated that priming alters motor and premotor activity. Here we sought to determine whether sensorimotor transmission is also modified. We report that changes in sensorimotor transmission do occur. We ask how they are mediated and obtain data that strongly suggest a presynaptic mechanism that involves changes in the \u201cbackground\u201d intracellular Ca<jats:sup>2+<\/jats:sup> concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>) in primary afferents themselves. This form of plasticity has previously been described and generated interest due to its potentially graded nature. Manipulations that alter the magnitude of the [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> impact the efficacy of synaptic transmission. It is, however, unclear how graded control is exerted under physiologically relevant conditions. In the feeding system changes in the background [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> are mediated by the induction of a nifedipine-sensitive current. We demonstrate that the extent to which this current is induced is altered by peptides (i.e., increased by a peptide released during the repetition priming of ingestive activity and decreased by a peptide released during the repetition priming of egestive activity). We suggest that this constitutes a behaviorally relevant mechanism for the graded control of synaptic transmission via the regulation of the [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in a neuron. <\/jats:p>","DOI":"10.1152\/jn.01082.2015","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:58:20Z","timestamp":1452733100000},"page":"1637-1643","source":"Crossref","is-referenced-by-count":4,"title":["Repetition priming-induced changes in sensorimotor transmission"],"prefix":"10.1152","volume":"115","author":[{"given":"Erik","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New 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