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To test this hypothesis, extracellular recordings of GPi neuronal activity were obtained during stereotactic surgery for the implantation of DBS electrodes in seven idiopathic CD and 14 PD patients. The mean GPi neuronal firing rate recorded from CD patients was lower than that in PD patients ( P &lt; 0.001; means \u00b1 SE: 71.4 \u00b1 2.2 and 91.7 \u00b1 3.0 Hz, respectively). Furthermore, GPi neurons fired in a more irregular pattern consisting of more frequent and longer pauses in CD compared with PD patients. When comparisons were done based on locations of recordings, these differences in firing rates and patterns were limited to the ventral portion of the GPi. In contrast, no difference in firing rate or pattern was observed in the globus pallidus externus between the two groups. These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders. <\/jats:p>","DOI":"10.1152\/jn.01107.2006","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T00:49:17Z","timestamp":1180572557000},"page":"720-729","source":"Crossref","is-referenced-by-count":129,"title":["Neuronal Firing Rates and Patterns in the Globus Pallidus Internus of Patients With Cervical Dystonia Differ From Those With Parkinson's Disease"],"prefix":"10.1152","volume":"98","author":[{"given":"Joyce K. 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