{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:29:47Z","timestamp":1772515787364,"version":"3.50.1"},"reference-count":39,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p> Cochlear hair cells express SK2, a small-conductance Ca<jats:sup>2+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup> channel thought to act in concert with Ca<jats:sup>2+<\/jats:sup>-permeable nicotinic acetylcholine receptors (nAChRs) \u03b19 and \u03b110 in mediating suppressive effects of the olivocochlear efferent innervation. To probe the in vivo role of SK2 channels in hearing, we examined gene expression, cochlear function, efferent suppression, and noise vulnerability in mice overexpressing SK2 channels. Cochlear thresholds, as measured by auditory brain stem responses and otoacoustic emissions, were normal in overexpressers as was overall cochlear morphology and the size, number, and distribution of efferent terminals on outer hair cells. Cochlear expression levels of SK2 channels were elevated eightfold without striking changes in other SK channels or in the \u03b19\/\u03b110 nAChRs. Shock-evoked efferent suppression of cochlear responses was significantly enhanced in overexpresser mice as seen previously in \u03b19 overexpresser mice; however, in contrast to \u03b19 overexpressers, SK2 overexpressers were not protected from acoustic injury. Results suggest that efferent-mediated cochlear protection is mediated by other downstream effects of ACh-mediated Ca<jats:sup>2+<\/jats:sup> entry different from those involving SK2-mediated hyperpolarization and the associated reduction in outer hair cell electromotility. <\/jats:p>","DOI":"10.1152\/jn.01183.2006","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T21:42:26Z","timestamp":1170452546000},"page":"2930-2936","source":"Crossref","is-referenced-by-count":26,"title":["Overexpression of SK2 Channels Enhances Efferent Suppression of Cochlear Responses Without Enhancing Noise Resistance"],"prefix":"10.1152","volume":"97","author":[{"given":"St\u00e9phane F.","family":"Maison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisan L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Adelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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