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A mistuned tone is a harmonic complex tone in which the frequency of one component has been changed; that component may be heard as a separate sound source, suggesting that the mistuned tone engages the same mechanisms that contribute to the segregation of natural sounds. In this study, the harmonic tone consisted of eight harmonics of 250 Hz; in the mistuned tone, the frequency of the fourth harmonic was increased by 12% (120 Hz). The mistuned tone elicited a stereotypical discharge pattern, consisting of peaks separated by about 8 ms and a response envelope modulated with a period of 100 ms, which bore little resemblance to the discharge pattern elicited by the harmonic tone or to the stimulus waveform. Similar discharge patterns were elicited from many neurons with a range of characteristic frequencies, especially from neurons that exhibited short-latency sustained responses to pure tones. In contrast, transient and long-latency neurons usually did not exhibit the stereotypical discharge pattern. The discharge pattern was generally stable when the stimulus level or component phase was varied; the major effect of these manipulations was to shift the phase of the response envelope. Simulation of IC responses with a computational model suggested that off-frequency inhibition could produce discharge patterns with these characteristics. <\/jats:p>","DOI":"10.1152\/jn.01194.2004","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T00:24:16Z","timestamp":1123115056000},"page":"3523-3537","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence of Stereotypical Responses to Mistuned Complex Tones in the Inferior Colliculus"],"prefix":"10.1152","volume":"94","author":[{"given":"Donal G.","family":"Sinex","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Velenovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1912474"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.4.2134"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Bregman AS. 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