{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:50:09Z","timestamp":1762113009892},"reference-count":47,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> We developed a new technique to isolate a whole guinea pig brain with an intact olfactory epithelium (OE) that enables us to access the ventral surface of the brain including olfactory areas with ease during natural odor stimulation. We applied odorants to OE and confirmed that odor-induced local field potentials (LFPs) could be induced in olfactory areas. In the olfactory bulb (OB) and the piriform cortex (PC), odor-induced LFPs consisted of a phasic initial component followed by a fast activity oscillation in the beta range (20 Hz). To understand the neural mechanisms of odor-induced responses especially in the anterior PC, we analyzed odor-induced LFPs, together with unit activity data. We confirmed that the initial component of odor-induced response has a characteristic temporal pattern, generated by a relatively weak direct afferent input, followed by an intra-cortical associative response, which was associated with a phasic inhibition. The beta oscillation might be formed by the repetition of these network activities. These electrophysiological data were consistent with the results of previous studies that used slice or in vivo preparations, suggesting that the olfactory neural network and activities of the brain are preserved in our new in vitro preparation. This study provides the basis for clarifying the sequence of neural activities underlying odor information processing in the brain in vitro following natural olfactory stimulation. <\/jats:p>","DOI":"10.1152\/jn.01366.2005","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T20:49:03Z","timestamp":1153946943000},"page":"670-679","source":"Crossref","is-referenced-by-count":19,"title":["Odor-Driven Activity in the Olfactory Cortex of an In Vitro Isolated Guinea Pig Whole Brain With Olfactory Epithelium"],"prefix":"10.1152","volume":"97","author":[{"given":"Takahiro","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ichiro","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"de Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Adrian ED. The electrical activity of the mammalian olfactory bulb. Electroencephalogr Clin Neurophysiol 2: 277\u2013388, 1950.","DOI":"10.1016\/0013-4694(50)90075-7"},{"key":"R1A","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(68)90119-4"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.2.204"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01020.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(96)00014-9"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02730.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01597.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91264-4"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(84)90128-7"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80200-7"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.5.561"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00092-X"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(98)00044-0"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450010402"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01712-6"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1179"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1178"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4673-04.2005"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1959.22.6.644"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1960.23.2.111"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90126-8"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1982.tb02598.x"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4365-05.2006"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03627.x"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1973.36.4.762"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.5.2531"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1786"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.112.3.541"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-09-03980.1993"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.1.248"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017287"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017288"},{"key":"R32","unstructured":"Llinas R, Yarom Y, and Sugimori M. Isolated mammalian brain in vitro: new technique for analysis of electrical activity of neuronal circuit function. Fed Proc 40: 2240\u20132245, 1981."},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04711.x"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.1.37"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.3.786"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00942.x"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00475.2003"},{"key":"R38","unstructured":"Neville KR and Haberly LB. Olfactory cortex. In: The Synaptic Organization of the Brain (5th ed.). New York: Oxford, 2004, p. 415\u2013454."},{"key":"R39","unstructured":"Ottoson D. Analysis of the electrical activity of the olfactory epithelium. Acta Physiol Scand 35, Suppl 122: 1\u201383, 1956."},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1983.50.1.89"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00551-7"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.042"},{"key":"R43","unstructured":"Uva L, Strowbridge BW, and de Curtis M. Olfactory bulb\/piriform cortex interactions in the in vitro isolated guinea pig brain. Soc Neurosci Abstr 279.2, 2005."},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91308-2"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.3.1425"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00543-X"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.01366.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:09:06Z","timestamp":1567991346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.01366.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1152\/jn.01366.2005"],"URL":"https:\/\/doi.org\/10.1152\/jn.01366.2005","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}