{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:08:20Z","timestamp":1791036500194,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:p> 1. We tested the hypothesis that long-term synaptic potentiation (LTP)-associated excitatory postsynaptic potential (EPSP)\/spike dissociation in the dentate gyrus (DG) is determined, in part, by changes in the feed-forward inhibition evoked by perforant path (PP) stimulation. The dentate commissural pathway (CP) and the PP activate a common pool of interneurons. Therefore a change in synaptic efficacy in the inhibitory circuit due to activation of one pathway could lead to changes in inhibitory efficacy in the other. The relationship between changes in feed-forward inhibition in the CP and EPSP\/spike (E-S) functions in the PP should provide information about the site(s) of synaptic modification. 2. In urethan-anesthetized rats, we measured the inhibition of evoked PP population spikes by the CP at interstimulus intervals of 6 and 12 ms. This measure of commissural inhibition and conventional E-S functions for the PP input to the DG were obtained before and after 1) PP tetany (400 Hz, 8-pulse trains) at low, medium, and high stimulus intensities, and 2) CP tetany (200 Hz, 7-pulse trains). 3. Low-intensity PP conditioning (just above population spike threshold) led to a decrease in CP inhibition and large left shifts of the E-S function. High- and medium-intensity PP conditioning yielded increases in commissural inhibition and smaller leftward E-S shifts. 4. Commissural conditioning led to increases in commissural inhibition and inconsistent changes in the E-S functions.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jn.1993.69.1.165","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T01:30:23Z","timestamp":1514165423000},"page":"165-173","source":"Crossref","is-referenced-by-count":19,"title":["Activity-mediated changes in feed-forward inhibition in the dentate commissural pathway: relationship to EPSP\/spike dissociation in the converging perforant path"],"prefix":"10.1152","volume":"69","author":[{"given":"R. A.","family":"Tomasulo","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.1993.69.1.165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:19:35Z","timestamp":1568006375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.1993.69.1.165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1,1]]}},"alternative-id":["10.1152\/jn.1993.69.1.165"],"URL":"https:\/\/doi.org\/10.1152\/jn.1993.69.1.165","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1,1]]}}}