{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:25:52Z","timestamp":1761395152711},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1993,7,1]]},"abstract":"<jats:p> 1. The alterations of voltage-sensitive calcium currents produced in thalamic cells by injury were investigated under voltage clamp using patch-clamp recordings in the whole-cell configuration. 2. One day after unilateral cortical ablation in immature rats (postnatal day 7), low-threshold transient calcium (T) currents in acutely isolated thalamic relay neurons (RNs) were increased by 68% compared with contralateral controls (P &lt; 0.001). Three days after the operation, T currents in injured neurons were at 44% of control levels (P &lt; 0.001). On the other hand, high-threshold (L) calcium currents in RNs did not change over the same interval. 3. To investigate the mechanism for the increase of T current, both kinetics and voltage dependency of activation and inactivation were examined. At a test voltage of -40 mV, the activation time constant decreased from 4.1 to 3.2 ms (P &lt; 0.05); however, this small change was insufficient to explain the large increase in T current. Time constants for both fast and slow inactivation did not change significantly, nor did voltage dependence of activation or inactivation of thalamic T currents. 4. Methyl-phenyl-succinimide (MPS, 1 mM), a compound known to block T currents, was used to examine possible alterations in the pharmacological properties of T channels after injury. MPS was more effective in reducing T currents in normal versus injured RNs (24 and 20% reductions, respectively; P &lt; 0.05), suggesting that pharmacological properties of T channels in the injured RNs may be different from those of the normal RNs.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jn.1993.70.1.20","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T02:29:03Z","timestamp":1514168943000},"page":"20-27","source":"Crossref","is-referenced-by-count":24,"title":["Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy"],"prefix":"10.1152","volume":"70","author":[{"given":"J. M.","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford UniversityMedical Center, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Huguenard","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford UniversityMedical Center, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford UniversityMedical Center, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.1993.70.1.20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:21:28Z","timestamp":1568006488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.1993.70.1.20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,7,1]]}},"alternative-id":["10.1152\/jn.1993.70.1.20"],"URL":"https:\/\/doi.org\/10.1152\/jn.1993.70.1.20","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7,1]]}}}