{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:43:12Z","timestamp":1784770992814,"version":"3.55.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1995,9,1]]},"abstract":"<jats:p> 1. Spontaneous activity and ectopic mechanical excitability of axotomized unmyelinated and myelinated fibers in the sural nerve were examined in anesthetized rats. The analysis was performed within 30 h after the nerve lesion using single-fiber recordings that were performed proximal to the severed nerve end. 2. Among all unmyelinated fibers tested (n = 865), 4-8% exhibited persistent spontaneous activity of low and irregular frequency. The percentage of spontaneously active C fibers did not change significantly during the first 30 h. Only 6 of 796 A fibers had spontaneous activity. 3. Mechanical stimulation of the cut nerve end excited 5-8% of all C fibers under investigation. No development with time could be detected in the frequency of mechanically excitable C fibers. In contrast, beginning 6 h after nerve transection, the number of mechanically excitable A fibers rose with time, reaching 27% after 22-30 h. 4. Among the A fibers (C fibers) that exhibited mechanical excitability or spontaneous activity, only 4% (25%) had both properties, whereas 96% (75%) were either mechanosensitive or spontaneously active. 5. With time after the nerve lesion, the mean discharge rate of all spontaneously discharging C fibers decreased significantly from 49 imp\/min (0.5-9 h after nerve lesion) to 11 imp\/min after 22-30 h. The mean discharge rate of C fibers exhibiting solely spontaneous activity and those C fibers that were additionally mechanosensitive did not differ significantly.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jn.1995.74.3.1020","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T18:18:29Z","timestamp":1514139509000},"page":"1020-1027","source":"Crossref","is-referenced-by-count":80,"title":["Development of spontaneous activity and mechanosensitivity in axotomized afferent nerve fibers during the first hours after nerve transection in rats"],"prefix":"10.1152","volume":"74","author":[{"given":"M.","family":"Michaelis","sequence":"first","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universitat, Kiel,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Blenk","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universitat, Kiel,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Janig","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universitat, Kiel,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Christian-Albrechts-Universitat, Kiel,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.1995.74.3.1020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:20:11Z","timestamp":1567992011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.1995.74.3.1020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9,1]]}},"alternative-id":["10.1152\/jn.1995.74.3.1020"],"URL":"https:\/\/doi.org\/10.1152\/jn.1995.74.3.1020","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9,1]]}}}