{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:59:12Z","timestamp":1790517552720,"version":"4.1.0"},"reference-count":54,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p> Frerking, Matthew, Salvador Borges, and Martin Wilson. Are some minis multiquantal? J. Neurophysiol. 78: 1293\u20131304, 1997. The amplitude distribution of miniature postsynaptic currents (minis) in many central neurons has a large variance and positive skew, but the sources of this variance and skew are unresolved. Recently it has been proposed that spontaneous Ca<jats:sup>2+<\/jats:sup> influx into a presynaptic bouton with multiple release sites could cause spontaneous multiquantal minis by synchronizing release at all sites in the bouton, accounting for both the large variance and skew of the mini distribution. We tested this hypothesis by evoking minis with internally perfused, buffered Ca<jats:sup>2+<\/jats:sup> and the secretagogue \u03b1-latrotoxin, both in the absence of external Ca<jats:sup>2+<\/jats:sup>. With these manipulations, the synchronized release model predicts that the mini distribution should collapse to a Gaussian distribution with a reduced coefficient of variation. Contrary to this expectation, we find that mini amplitude distributions under these conditions retain a large variance and positive skew and are indistinguishable from amplitude distributions of depolarization-evoked minis, strongly suggesting that minis are uniquantal. <\/jats:p>","DOI":"10.1152\/jn.1997.78.3.1293","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T01:25:30Z","timestamp":1514165130000},"page":"1293-1304","source":"Crossref","is-referenced-by-count":34,"title":["Are Some Minis Multiquantal?"],"prefix":"10.1152","volume":"78","author":[{"given":"Matthew","family":"Frerking","sequence":"first","affiliation":[{"name":"Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, University of California, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Borges","sequence":"additional","affiliation":[{"name":"Section of Neurobiology, Physiology and Behavior, 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