{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:14:53Z","timestamp":1789449293131,"version":"build-2803163510"},"reference-count":20,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p> Messaoudi, Elhoucine, Kjetil B\u00e5rdsen, Bolek Srebro, and Clive R. Bramham. Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentategyrus. J. Neurophysiol. 79: 496\u2013499, 1998. The effect of acuteintrahippocampal infusion of brain-derived neurotrophic factor (BDNF) on synaptic transmission in the dentate gyrus was investigated in urethan-anesthetized rats. Medial perforant path-evoked field potentials were recorded in the dentate hilus and BDNF-containing buffer was infused (4 \u03bcl, 25 min) immediately above the dentate molecular layer. BDNF led to a slowly developing increase of the field excitatory postsynaptic potential (fEPSP) slope and population spike amplitude. The potentiation either reached a plateau level at \u223c2 h after BDNF infusion or continued to increase for the duration of experiment; the longest time point recorded was 10 h. Mean increases at 4 h after BDNF infusion were 62.2 and 224% for the fEPSP slope and population spike, respectively. No changes in responses were observed in controls receiving buffer medium only or buffer containing cytochrome C. BDNF-induced potentiation developed in the absence of epileptiform activity in the hippocampal electroencephalogram or changes in recurrent inhibition on granule cells as assessed by paired-pulse inhibition of the population spike. We conclude that exogenous BDNF induces a lasting potentiation of synaptic efficacy in the dentate gyrus of anesthetized adult rats. <\/jats:p>","DOI":"10.1152\/jn.1998.79.1.496","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T07:16:33Z","timestamp":1514186193000},"page":"496-499","source":"Crossref","is-referenced-by-count":176,"title":["Acute Intrahippocampal Infusion of BDNF Induces Lasting Potentiation of Synaptic Transmission in the Rat Dentate Gyrus"],"prefix":"10.1152","volume":"79","author":[{"given":"Elhoucine","family":"Messaoudi","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"B\u00e5rdsen","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolek","family":"Srebro","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive R.","family":"Bramham","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00062.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960506)368:3<371::AID-CNE4>3.0.CO;2-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02295.1997"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00703.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/381706a0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960506)368:3<413::AID-CNE7>3.0.CO;2-8"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.7886457"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1101\/lm.3.2-3.188"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0087"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8856"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199412300-00007"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.8074"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.001445"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0030"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-10-03189.1996"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80140-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/381702a0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-09-02959.1997"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5236.593"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970203)378:1<135::AID-CNE8>3.0.CO;2-5"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.1998.79.1.496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:23:13Z","timestamp":1568006593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.1998.79.1.496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1152\/jn.1998.79.1.496"],"URL":"https:\/\/doi.org\/10.1152\/jn.1998.79.1.496","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}