{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:49:17Z","timestamp":1767084557300},"reference-count":38,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>Zhainazarov, Aslbek B., Richard E. Doolin, and Barry W. Ache. Sodium-gated cation channel implicated in the activation of lobster olfactory receptor neurons. J. Neurophysiol. 79: 1349\u20131359, 1998. The role of Na<jats:sup>+<\/jats:sup>-activated channels in cellular function, if any, is still elusive. We have attempted to implicate a Na<jats:sup>+<\/jats:sup>-activated nonselective cation channel in the activation of lobster olfactory receptor neurons. We show that a Na<jats:sup>+<\/jats:sup>-activated channel occurs in the odor-detecting outer dendrites. With the use of pharmacological blockers of the channel together with ion substitution, we show that a substantial part of the odor-evoked depolarization in these cells can be ascribed to a Na<jats:sup>+<\/jats:sup>-activated conductance. We hypothesize, therefore, that the Na<jats:sup>+<\/jats:sup>-activated channel amplifies the receptor current as a result of being secondarily activated by the primary odor transduction pathway.<\/jats:p>","DOI":"10.1152\/jn.1998.79.3.1349","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T07:08:18Z","timestamp":1514185698000},"page":"1349-1359","source":"Crossref","is-referenced-by-count":16,"title":["Sodium-Gated Cation Channel Implicated in the Activation of Lobster Olfactory Receptor Neurons"],"prefix":"10.1152","volume":"79","author":[{"given":"Aslbek B.","family":"Zhainazarov","sequence":"first","affiliation":[{"name":"Whitney Laboratory,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Doolin","sequence":"additional","affiliation":[{"name":"Whitney Laboratory,"},{"name":"Department of Neuroscience, University of Florida, St. Augustine, Florida 32086-8623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry W.","family":"Ache","sequence":"additional","affiliation":[{"name":"Whitney Laboratory,"},{"name":"Department of Zoology, and"},{"name":"Department of Neuroscience, University of Florida, St. Augustine, Florida 32086-8623"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90145-H"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430130110043"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/361315a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90093-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90488-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5718"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90243-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91403-X"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215452"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6264"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01868532"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90360-G"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-06-01674.1991"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370749"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90089-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/363071a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/366283a0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(90)90033-N"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-03979.1992"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.65.3.446"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90191-9"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(87)90010-0"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13543.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(92)07008-C"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.266.6.C1538"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.54.030192.000411"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021216"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1981.61.2.296"},{"key":"B33","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1242\/jeb.155.1.531","volume":"155","author":"Sanchez-Armass S.","year":"1991","journal-title":"J. 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