{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:26:30Z","timestamp":1791426390844,"version":"4.3.3"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p> Selective Induction of LTP and LTD by Postsynaptic [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> Elevation. Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(\u03b2-aminoethyl ether)- N, N, N\u2032, N\u2032-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> with relatively high magnitude, which mimics the [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information. <\/jats:p>","DOI":"10.1152\/jn.1999.81.2.781","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T04:55:39Z","timestamp":1514177739000},"page":"781-787","source":"Crossref","is-referenced-by-count":478,"title":["Selective Induction of LTP and LTD by Postsynaptic [Ca<sup>2+<\/sup>]<sub>i<\/sub> Elevation"],"prefix":"10.1152","volume":"81","author":[{"given":"Shao-Nian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Gui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Zucker","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90081-V"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/368740a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.2.953"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-01-00180.1992"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80102-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5348.227"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/386855a0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-02910.1993"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.1.187"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79644-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81247-7"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-03-00774.1987"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79653-4"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1346729"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90094-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90075-O"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.93.6.1017"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.001535"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9574"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90121-F"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90227-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90248-C"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90238-M"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80081-1"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.5.2157"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00874-6"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90269-4"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582316"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-11-04202.1992"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X_5_1_002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)61109-7"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.1999.81.2.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:26:06Z","timestamp":1568003166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.1999.81.2.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2,1]]}},"alternative-id":["10.1152\/jn.1999.81.2.781"],"URL":"https:\/\/doi.org\/10.1152\/jn.1999.81.2.781","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,1]]}}}