{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:14:11Z","timestamp":1791296051423,"version":"4.1.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1999,11,1]]},"abstract":"<jats:p>Mechanoelectrical transducer currents in turtle auditory hair cells adapted to maintained stimuli via a Ca<jats:sup>2+<\/jats:sup>-dependent mechanism characterized by two time constants of \u223c1 and 15 ms. The time course of adaptation slowed as the stimulus intensity was raised because of an increased prominence of the second component. The fast component of adaptation had a similar time constant for both positive and negative displacements and was unaffected by the myosin ATPase inhibitors, vanadate and butanedione monoxime. Adaptation was modeled by a scheme in which Ca<jats:sup>2+<\/jats:sup>ions, entering through open transducer channels, bind at two intracellular sites to trigger independent processes leading to channel closure. It was assumed that the second site activates a modulator with 10-fold slower kinetics than the first site. The model was implemented by computing Ca<jats:sup>2+<\/jats:sup>diffusion within a single stereocilium, incorporating intracellular calcium buffers and extrusion via a plasma membrane CaATPase. The theoretical results reproduced several features of the experimental responses, including sensitivity to the concentration of external Ca<jats:sup>2+<\/jats:sup>and intracellular calcium buffer and a dependence on the onset speed of the stimulus. The model also generated damped oscillatory transducer responses at a frequency dependent on the rate constant for the fast adaptive process. The properties of fast adaptation make it unlikely to be mediated by a myosin motor, and we suggest that it may result from Ca<jats:sup>2+<\/jats:sup>binding to the transducer channel or a nearby cytoskeletal element.<\/jats:p>","DOI":"10.1152\/jn.1999.82.5.2171","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T12:53:11Z","timestamp":1513860791000},"page":"2171-2181","source":"Crossref","is-referenced-by-count":151,"title":["Two Components of Transducer Adaptation in Auditory Hair Cells"],"prefix":"10.1152","volume":"82","author":[{"given":"Yuh-Cherng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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