{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:48:38Z","timestamp":1790970518716,"version":"4.1.0"},"reference-count":63,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p> A critical role of Ca<jats:sup>2+<\/jats:sup> in vertebrate olfactory receptor neurons (ORNs) is to couple odor-induced excitation to intracellular feedback pathways that are responsible for the regulation of the sensitivity of the sense of smell, but the role of intracellular Ca<jats:sup>2+<\/jats:sup> stores in this process remains unclear. Using confocal Ca<jats:sup>2+<\/jats:sup> imaging and perforated patch recording, we show that salamander ORNs contain a releasable pool of Ca<jats:sup>2+<\/jats:sup> that can be discharged at rest by the SERCA inhibitor thapsigargin and the ryanodine receptor agonist caffeine. The Ca<jats:sup>2+<\/jats:sup> stores are spatially restricted; emptying produces compartmentalized Ca<jats:sup>2+<\/jats:sup> release and capacitative-like Ca<jats:sup>2+<\/jats:sup> entry in the dendrite and soma but not in the cilia, the site of odor transduction. We deplete the stores to show that odor stimulation causes store-dependent Ca<jats:sup>2+<\/jats:sup> mobilization. This odor-induced Ca<jats:sup>2+<\/jats:sup> release does not seem to be necessary for generation of an immediate electrophysiological response, nor does it contribute significantly to the Ca<jats:sup>2+<\/jats:sup> transients in the olfactory cilia. Rather, it is important for amplifying the magnitude and duration of Ca<jats:sup>2+<\/jats:sup> transients in the dendrite and soma and is thus necessary for the spread of an odor-induced Ca<jats:sup>2+<\/jats:sup> wave from the cilia to the soma. We show that this amplification process depends on Ca<jats:sup>2+<\/jats:sup>-induced Ca<jats:sup>2+<\/jats:sup> release. The results indicate that stimulation of ORNs with odorants can produce Ca<jats:sup>2+<\/jats:sup> mobilization from intracellular stores without an immediate effect on the receptor potential. Odor-induced, store-dependent Ca<jats:sup>2+<\/jats:sup> mobilization may be part of a feedback pathway by which information is transferred from the distal dendrite of an ORN to its soma. <\/jats:p>","DOI":"10.1152\/jn.2000.83.1.501","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T12:32:49Z","timestamp":1513859569000},"page":"501-512","source":"Crossref","is-referenced-by-count":62,"title":["Amplification of Odor-Induced Ca<sup>2+<\/sup> Transients by Store-Operated Ca<sup>2+<\/sup> Release and Its Role in Olfactory Signal Transduction"],"prefix":"10.1152","volume":"83","author":[{"given":"Frank","family":"Zufall","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trese","family":"Leinders-Zufall","sequence":"additional","affiliation":[{"name":"Department of Anatomy and 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