{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:14:11Z","timestamp":1789740851195,"version":"4.0.1"},"reference-count":15,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:p> We obtained rat brain slices (550\u2013650 \u03bcm) that contained part of the frontoparietal cortex along with a portion of the thalamic ventrobasal complex (VB) and of the reticular nucleus (RTN). Maintained reciprocal thalamocortical connectivity was demonstrated by VB stimulation, which elicited orthodromic and antidromic responses in the cortex, along with re-entry of thalamocortical firing originating in VB neurons excited by cortical output activity. In addition, orthodromic responses were recorded in VB and RTN following stimuli delivered in the cortex. Spontaneous and stimulus-induced coherent rhythmic oscillations (duration = 0.4\u20133.5 s; frequency = 9\u201316 Hz) occurred in cortex, VB, and RTN during application of medium containing low concentrations of the K<jats:sup>+<\/jats:sup> channel blocker 4-aminopyridine (0.5\u20131 \u03bcM). This activity, which resembled electroencephalograph (EEG) spindles recorded in vivo, disappeared in both cortex and thalamus during application of the excitatory amino acid receptor antagonist kynurenic acid in VB ( n = 6). By contrast, cortical application of kynurenic acid ( n = 4) abolished spindle-like oscillations at this site, but not those recorded in VB, where their frequency was higher than under control conditions. Our findings demonstrate the preservation of reciprocally interconnected cortical and thalamic neuron networks that generate thalamocortical spindle-like oscillations in an in vitro rat brain slice. As shown in intact animals, these oscillations originate in the thalamus where they are presumably caused by interactions between RTN and VB neurons. We propose that this preparation may help to analyze thalamocortical synchronization and to understand the physiopathogenesis of absence attacks. <\/jats:p>","DOI":"10.1152\/jn.2000.84.2.1093","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:22:37Z","timestamp":1513862557000},"page":"1093-1097","source":"Crossref","is-referenced-by-count":34,"title":["Spindle-Like Thalamocortical Synchronization in a Rat Brain  Slice Preparation"],"prefix":"10.1152","volume":"84","author":[{"given":"Virginia","family":"Tancredi","sequence":"first","affiliation":[{"name":"Dipartimento di Neuroscienze, Universit\u00e0 degli Studi di Roma \u2018Tor Vergata\u2019, 00173 Rome;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biagini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Universit\u00e0 degli Studi di Modena e Reggio Emilia, 41100 Modena, Italy;"},{"name":"Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"D'Antuono","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Louvel","sequence":"additional","affiliation":[{"name":"Centre P. Broca and Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U109, 75014 Paris; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Pumain","sequence":"additional","affiliation":[{"name":"Centre P. Broca and Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U109, 75014 Paris; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Avoli","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U398, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90333-J"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90252-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90381-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.1726"},{"key":"B7","first-page":"8","volume":"40","author":"Blumenfeld H","year":"1999","journal-title":"Epilepsia"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016471"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00017-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-02865.1999"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-22-09500.1998"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-01-00104.1992"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050234"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.54.6.1473"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235588"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90085-X"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(95)00079-8"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.2000.84.2.1093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:21:39Z","timestamp":1568002899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.2000.84.2.1093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8,1]]}},"alternative-id":["10.1152\/jn.2000.84.2.1093"],"URL":"https:\/\/doi.org\/10.1152\/jn.2000.84.2.1093","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,1]]}}}