{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:30:05Z","timestamp":1789615805886,"version":"build-2803163510"},"reference-count":171,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH128082"],"award-info":[{"award-number":["MH128082"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH134761"],"award-info":[{"award-number":["MH134761"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS137812"],"award-info":[{"award-number":["NS137812"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>Substance use and its associated comorbidities are a global public health crisis affecting millions of people, involving both legal and illicit substances, including cocaine, opioids, methamphetamine, fentanyl, alcohol, and marijuana. Currently, most of the research in drug abuse has been focused on the drug-mediated dysregulation of the monoaminergic and glutamatergic brain pathways because of their role in addiction, tolerance, dependence, withdrawal, and relapse. In addition, individuals using cocaine (acute and chronic) also exhibit signs of peripheral compromise, affecting the cardiovascular system, immune function, and multiple aging processes. However, the underlying mechanisms remain incompletely understood. Recently, emerging mechanisms of drug action, independent of neurotransmitter dysregulation, have been described in nonneuronal cells, helping to explain the significant burden of cardiovascular disease, immune compromise, and sudden death in the drug user population.<\/jats:p>","DOI":"10.1152\/physiol.00004.2025","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T17:00:31Z","timestamp":1758560431000},"page":"159-171","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cocaine-Induced Cardiovascular and Immune Dysfunction: Emerging Mechanisms"],"prefix":"10.1152","volume":"41","author":[{"given":"Kyce","family":"Darouiche","sequence":"first","affiliation":[{"name":"The University of Texas Medical Branch (UTMB)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Devin","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch (UTMB)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Valdebenito","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch (UTMB)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ajasin","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch (UTMB)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-4720","authenticated-orcid":false,"given":"Eliseo","family":"Eugenin","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch (UTMB)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1937"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113956"},{"key":"B3","first-page":"37","volume":"47","author":"Roncero C","year":"2019","journal-title":"Actas Esp Psiquiatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.1.1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2673-16.2016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01112-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76273-1"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256574"},{"key":"B9","first-page":"76","volume":"7","author":"Qureshi AI","year":"2014","journal-title":"J Vasc Interv Neurol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90832-v"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(00)00639-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.08.061"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0577-22.2022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199710)27:2<95::AID-SYN1>3.0.CO;2-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_23"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.07.039"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2023-22.2022"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13026"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.12.033"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13334"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.069"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/genes8050138"},{"key":"B23","doi-asserted-by":"publisher","unstructured":"Matt SM, Nolan R, Manikandan S, Agarwal Y, Channer B, Oteju O, Daniali M, Canagarajah JA, LuPone T, Mompho K, Runner K, Nickoloff-Bybel E, Li B, Niu M, Schlachetzki JC, Fox HS, Gaskill PJ. Dopamine-driven increase in IL-1beta in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIV (Preprint). bioRxiv 2024.06.09.598137, 2024. doi:10.1101\/2024.06.09.598137. 38915663","DOI":"10.1101\/2024.06.09.598137"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.122.000618"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.043"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.05.009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2013.10.015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00032-w"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.03.019"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(98)00008-3"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.06.018"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110113"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001161"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(94)01086-z"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108232"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.08.191"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(03)01723-0"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00017"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934052"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.122044"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12482"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27487"},{"key":"B43","doi-asserted-by":"publisher","unstructured":"Sharma AL, Tyagi P, Khumallambam M, Tyagi M. Cocaine-induced DNA-PK relieves RNAP II pausing by promoting TRIM28 phosphorylation (Preprint). bioRxiv 2024.08.19.608673, 2024. doi:10.1101\/2024.08.19.608673. 39229050","DOI":"10.1101\/2024.08.19.608673"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cells13231950"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.09.050"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.006"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.01.009"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-005-0755-6"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.06.027"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.188950"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14594"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2019180031"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/18-048"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108023450507"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.5.385"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1006\/biol.1994.1061"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.01.040"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2007.759"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104714"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000740"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-3057(01)00482-8"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90212-8"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90292-9"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165121.50527.DE"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab264"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV22015"},{"key":"B67","first-page":"842","volume":"113","author":"Peng SK","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1998.4683"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146426"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201712011"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37495-6"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051475"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.06.004"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz553"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033427"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0977"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914279"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp557"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq428"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.08.037"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1111\/add.12691"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-014-9255-1"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw435"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.03.021"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.04.025"},{"key":"B86","first-page":"9135","volume":"23","author":"Ripoll T","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2020.03.030"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsigen.2022.102723"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2023.111908"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2023-209351"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1994.tb04003.x"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.99.21.2737"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/19.6.459"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/21.6.465"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/16.5.311"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/26.7.382"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199310000-00008"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-7-556"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1080\/00952990903075034"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(94)01060-x"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1086\/318131"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06079-8"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02435"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112445"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1036"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(89)90139-2"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.130.4.1658"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01074.x"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.12.014"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01622-15"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00846-6"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3201\/eid1311.070148"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.11.024"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.023"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.03.045"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(93)90144-n"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(95)00017-v"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3109\/08923979109019688"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000118960.58334.a9"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051387"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00823"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.3.698"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2020.18.1.32"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew256"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1170"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02324-z"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87728-4"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0145-0"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.019"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-017-9440-0"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.112797"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12156"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4579"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.004"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1251"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(02)02289-0"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7597"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.04.019"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5273(02)00394-7"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-10007-6"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020804"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4607"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2020.1828439"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.47626\/2237-6089-2023-0723"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.05.013"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2012\/15\/ES9"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2019.11.641"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.05.005"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110210"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.941360"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2023.2220875"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7019"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000004077"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2003.11.031"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198506273122611"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.687814"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.102"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2014.16.3\/pkenny"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38836"},{"key":"B162","first-page":"437","volume":"85","author":"McCarthy DM","year":"2012","journal-title":"Yale J Biol Med"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3172-20.2022"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115951"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.05.005"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.04.013"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/nn0910-1039"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.05.017"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000972"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.128"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2018-0092"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiol.00004.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:41:04Z","timestamp":1770842464000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.00004.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":171,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1152\/physiol.00004.2025"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00004.2025","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}