{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:48:22Z","timestamp":1792000102882,"version":"4.4.0"},"reference-count":206,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Techonology Major Project","award":["2025ZD0547100"],"award-info":[{"award-number":["2025ZD0547100"]}]},{"name":"National Natural Science Foundation of China","award":["82570345"],"award-info":[{"award-number":["82570345"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["82225005"],"award-info":[{"award-number":["82225005"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technolology Commission of Shanghai Municipality","award":["23410750100"],"award-info":[{"award-number":["23410750100"]}],"id":[{"id":"https:\/\/ror.org\/03kt66j61","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the \u201cDawn\u201d Program of Shanghai Education Commission","award":["24SG36"],"award-info":[{"award-number":["24SG36"]}]},{"name":"the Oriental Scholars of Shanghai Universities","award":["TP2022057"],"award-info":[{"award-number":["TP2022057"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20250996"],"award-info":[{"award-number":["GZC20250996"]}]},{"name":"Shanghai Postdoctoral Excellence Program","award":["2024240"],"award-info":[{"award-number":["2024240"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2027,1,1]]},"abstract":"<jats:p>Exercise is a highly cost-effective and nonpharmacological intervention for maintaining cardiovascular health and treating heart disease. Exercise can protect the heart through multiple effects, including the regulation of cardiomyocytes and noncardiomyocytes. Immune cells can be regulated upon exercise under both physiological and pathological conditions. The present review presents the current knowledge and research advances about how exercise protects the heart, especially deciphering the regulation of cardiomyocytes and the immune microenvironment by exercise. This review introduces the effect of exercise on the infiltration, phenotypic plasticity, and activation of innate and adaptive immune cells, alongside their interactions with other cellular components within the cardiac immune microenvironment. Moreover, we address the role of lymphatic vessels in regulating immune cell trafficking and activation, as well as the effects of exercise on cardiac lymphangiogenesis. It further discusses the application of multiomics approaches in investigating exercise-induced cardiac adaptations, explores potential therapeutic strategies targeting the cardiac immune microenvironment, and highlights the cardiotoxicity risks associated with excessive exercise. A deep understanding of the effects of exercise on cardiomyocytes and cardiac immune microenvironment will pave the way to promote exercise interventions and the development of exercise mimetics in the treatment of heart diseases.<\/jats:p>","DOI":"10.1152\/physiol.00008.2026","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:31:39Z","timestamp":1776666699000},"page":"000-000","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimized Cardiac Health by Exercise: Cardiomyocytes and Immune Microenvironment"],"prefix":"10.1152","volume":"42","author":[{"given":"Shuqin","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Science","place":["China"]},{"name":"Shanghai University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Life Science","place":["China"]},{"name":"Shanghai University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science","place":["China"]},{"name":"Shanghai University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Li","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Cretoiu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Romania"]},{"name":"Alessandrescu-Rusescu National Institute for Mother and Child Health","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-2474","authenticated-orcid":false,"given":"T. Scott","family":"Bowen","sequence":"additional","affiliation":[{"name":"University of Leeds","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P. G.","family":"Sluijter","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["The Netherlands"]},{"name":"UMC Utrecht Regenerative Medicine Center, Circulatory Health Research Center, University Medical Center, Utrecht University","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Bei","sequence":"additional","affiliation":[{"name":"School of Life Science","place":["China"]},{"name":"Shanghai University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-0003","authenticated-orcid":false,"given":"Junjie","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Life Science","place":["China"]},{"name":"Shanghai University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-077025"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2022.10.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/hco.0000000000000563"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30383-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112338-20211119-00903"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.123117"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.Cir.0000121360.31954.1f"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.124.325533"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.47180"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy304"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003831"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2022.12.011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2022.02.005"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70043"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-022-09758-1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.85"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12091975"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-024-00027-z"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.12.007"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.004"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.073"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2020.1735684"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-025-01279-z"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102748"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200204"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.124.036555"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.122.059631"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.08.003"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102693"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04684.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0787-1"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.123.067592"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.99.1.65"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.102.15.1814"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00407.2009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.11.009"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606663104"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4304-8_12"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.036"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0007-y"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.014"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.050446"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad161"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.109917"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nri3800"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230719"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.599511"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0065-8"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.008788"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.121.318005"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.122.062984"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00305-3"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.07.047"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218312"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2025.40.S1.0725"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.38"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00097.2020"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.121.319478"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44669-y"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.115489"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1042\/bj3350111"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.121.057549"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.311327"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.031"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4428"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21737-9"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.02.006"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19297-5"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.019"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.020"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/jci74783"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.11.012"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.115.303794"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.11.015"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400486"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00617-1"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1172\/jci94753"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/359693a0"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010058"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34971-6"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08008-5"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57613-8_4"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201870"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06558.x"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03940.x"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1261\/rna.079266.122"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.021"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.209296"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.078436"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132733"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01105-4"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn3027"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0781-7"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1078512"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1616-2"},{"key":"B99","first-page":"143","volume":"46","author":"Bouillon LE","year":"2006","journal-title":"J Sports Med Phys Fitness"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.02.011"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.08.017"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.10.1315"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1021297"},{"key":"B104","first-page":"8","volume":"14","author":"Timmons BW","year":"2008","journal-title":"Exerc Immunol Rev"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2022.100415"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1024839"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70104"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120557"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-67443-8"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010602"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00135.2025"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07359-5"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.123.323346"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-30174-3"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.121.008550"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1617261"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02220-z"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235028"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8148742"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0633-x"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2253"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972668"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22915"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiaf017"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxac029"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1172\/jci194664"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01497-2"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01331.2003"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112849"},{"key":"B130","first-page":"129","volume":"10","author":"Peake J","year":"2004","journal-title":"Exerc Immunol Rev"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199417040-00005"},{"key":"B132","first-page":"45","volume":"67","author":"Kumral ZN","year":"2016","journal-title":"J Physiol Pharmacol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1113\/ep091362"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000000980"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00455-6"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.817377"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.11.023"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2020.151909"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510997103"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.82.6.2003"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.05.007"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.1.203"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.123.010569"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.011"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.7150\/thno.126053"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154008"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01471-y"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1172\/jci185218"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2023.1120454"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.70037"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.035"},{"key":"B152","first-page":"14","volume":"16","author":"Raygan F","year":"2017","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074722"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-018-9794-0"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816026e7"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00622.2016"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.06.023"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2023.10.002"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01722-4"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12744"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.4.1442"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1590\/s1516-31802003000100003"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.01.013"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11226814"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-022-00956-1"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971958"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1080\/02640410701716790"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-022-02760-1"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2000.t01-7-.x"},{"key":"B171","first-page":"185","volume":"3","author":"Hejazi K","year":"2012","journal-title":"Asian J Sports Med"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.122.321672"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037176"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00489-x"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1557250"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17827"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00711-4"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1172\/jci97192"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.120.314370"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313314"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.123.065935"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.124.071741"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.115.020143"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/nature14483"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.016"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2023.100380"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.150"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06877-w"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2025.101027"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00128-0"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01153-1"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104615"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108635"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.001"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.005"},{"key":"B196","first-page":"89","volume":"111","author":"Schwartz RS","year":"2014","journal-title":"Mo Med"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.05.006"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.125.018470"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00660-w"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26799"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.938282"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61874-x"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.11.004"},{"key":"B204","first-page":"6","volume":"17","author":"Walsh NP","year":"2011","journal-title":"Exerc Immunol Rev"},{"key":"B205","first-page":"64","volume":"17","author":"Walsh NP","year":"2011","journal-title":"Exerc Immunol Rev"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00648"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiol.00008.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:08:33Z","timestamp":1791997713000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.00008.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1,1]]},"references-count":206,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1,1]]}},"alternative-id":["10.1152\/physiol.00008.2026"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00008.2026","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2027,1,1]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}