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These low IH doses upregulate hypoxia-sensitive growth\/trophic factors within respiratory motoneurons but do not elicit detectable pathologies such as hippocampal cell death, neuroinflammation, or systemic hypertension. Recent advances have been made toward understanding cellular mechanisms giving rise to IH-induced respiratory plasticity, and attempts have been made to harness the benefits of low-dose IH to treat respiratory insufficiency after cervical spinal injury. Our recent realization that IH also upregulates growth\/trophic factors in nonrespiratory motoneurons and improves limb (or leg) function after incomplete chronic spinal injuries suggests that IH-induced plasticity is a general feature of motor systems. Collectively, available evidence suggests that low-dose IH may represent a safe and effective treatment to restore lost motor function in diverse clinical disorders that impair motor function.<\/jats:p>","DOI":"10.1152\/physiol.00012.2013","type":"journal-article","created":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T17:17:42Z","timestamp":1388596662000},"page":"39-48","source":"Crossref","is-referenced-by-count":117,"title":["Unexpected Benefits of Intermittent Hypoxia: Enhanced Respiratory and Nonrespiratory Motor Function"],"prefix":"10.1152","volume":"29","author":[{"given":"E. 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