{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:03:04Z","timestamp":1778220184134,"version":"3.51.4"},"reference-count":92,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL122228"],"award-info":[{"award-number":["R01HL122228"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137807"],"award-info":[{"award-number":["R01HL137807"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p> Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies. <\/jats:p>","DOI":"10.1152\/physiol.00014.2019","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T13:31:24Z","timestamp":1575466284000},"page":"57-68","source":"Crossref","is-referenced-by-count":20,"title":["Molecular\/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators"],"prefix":"10.1152","volume":"35","author":[{"given":"Bradley J.","family":"Undem","sequence":"first","affiliation":[{"name":"Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61255-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005703"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1201\/9780203492314.pt1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00052.2017"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00802-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0665OC"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.057885"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043422"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00313.2017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90382.2008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/35082088"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.109371"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2004.12.010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014770"},{"key":"B16","first-page":"372","volume":"34","author":"Coleridge HM","year":"1975","journal-title":"Fed Proc"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4009-6_32"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0027715"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1984.tb10750.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-24-j0001.1999"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013772"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1813OC"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00378"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019802"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8650"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000040"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201443"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2117"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004184"},{"key":"B30","first-page":"682","volume":"289","author":"Kajekar R","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90019-S"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.3.511"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.011"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.192971"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001231"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/JP275698"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.054890"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022848"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90075-3"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10754"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000010080.62031.f0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90239-X"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.146365"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90360.2008"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.181669"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.2.202"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.5.1955"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.5.2032"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130020"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087577"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00411"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41084"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5637-12.2013"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.121582"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00106.2006"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093153"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(99)00075-2"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.6_Pt_2.S65"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5128-14.2015"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00028.2013"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.215384"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.148379"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.195339"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.084319"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.066381"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1955.sp001116"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008877"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1113\/JP277521"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021142"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/BF00652619"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.suppl_4.S69"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.237115"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/35050121"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.6.1823"},{"key":"B76","volume-title":"The Integrated Action of the Nervous System","author":"Sherrington C","year":"1906"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152002699"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.11.002"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.15424\/bioelectronmed.2016.00007"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124467"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-20-07531.2000"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.054445"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.196"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.183301"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.040832"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.060079"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009555"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185985"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122058"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.113308"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079574"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiol.00014.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T13:31:33Z","timestamp":1575466293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiol.00014.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["10.1152\/physiol.00014.2019"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00014.2019","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}