{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:18:55Z","timestamp":1790734735881,"version":"4.1.0"},"reference-count":202,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL124070"],"award-info":[{"award-number":["R01HL124070"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL141353"],"award-info":[{"award-number":["R01HL141353"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F30HL165806"],"award-info":[{"award-number":["F30HL165806"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017995","name":"Nora Eccles Treadwell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> Oxidative phosphorylation is regulated by mitochondrial calcium (Ca<jats:sup>2+<\/jats:sup>) in health and disease. In physiological states, Ca<jats:sup>2+<\/jats:sup> enters via the mitochondrial Ca<jats:sup>2+<\/jats:sup> uniporter and rapidly enhances NADH and ATP production. However, maintaining Ca<jats:sup>2+<\/jats:sup> homeostasis is critical: insufficient Ca<jats:sup>2+<\/jats:sup> impairs stress adaptation, and Ca<jats:sup>2+<\/jats:sup> overload can trigger cell death. In this review, we delve into recent insights further defining the relationship between mitochondrial Ca<jats:sup>2+<\/jats:sup> dynamics and oxidative phosphorylation. Our focus is on how such regulation affects cardiac function in health and disease, including heart failure, ischemia-reperfusion, arrhythmias, catecholaminergic polymorphic ventricular tachycardia, mitochondrial cardiomyopathies, Barth syndrome, and Friedreich\u2019s ataxia. Several themes emerge from recent data. First, mitochondrial Ca<jats:sup>2+<\/jats:sup> regulation is critical for fuel substrate selection, metabolite import, and matching of ATP supply to demand. Second, mitochondrial Ca<jats:sup>2+<\/jats:sup> regulates both the production and response to reactive oxygen species (ROS), and the balance between its pro- and antioxidant effects is key to how it contributes to physiological and pathological states. Third, Ca<jats:sup>2+<\/jats:sup> exerts localized effects on the electron transport chain (ETC), not through traditional allosteric mechanisms but rather indirectly. These effects hinge on specific transporters, such as the uniporter or the Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup> exchanger, and may not be noticeable acutely, contributing differently to phenotypes depending on whether Ca<jats:sup>2+<\/jats:sup> transporters are acutely or chronically modified. Perturbations in these novel relationships during disease states may either serve as compensatory mechanisms or exacerbate impairments in oxidative phosphorylation. Consequently, targeting mitochondrial Ca<jats:sup>2+<\/jats:sup> holds promise as a therapeutic strategy for a variety of cardiac diseases characterized by contractile failure or arrhythmias. <\/jats:p>","DOI":"10.1152\/physiol.00014.2024","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T14:17:55Z","timestamp":1715091475000},"page":"247-268","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease"],"prefix":"10.1152","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-9272","authenticated-orcid":false,"given":"Enrique","family":"Balderas","sequence":"first","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra H. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj K.","family":"Rai","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Mollinedo","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Duron","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-7334","authenticated-orcid":false,"given":"Dipayan","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States"},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Biochemistry, Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.028"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13427"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300501"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/286845a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(80)90205-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1021\/bi2018909"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.10.019"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/JP273609"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00108"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2021.102356"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4039"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1088\/978-0-7503-2009-2ch12"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037968"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316369"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908099107"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nature22082"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175145"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.02.018"},{"key":"B19","doi-asserted-by":"publisher","unstructured":"Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. TMEM65 regulates NCLX-dependent mitochondrial calcium efflux (Preprint). bioRxiv 2023.10.06.561062, 2023. doi:10.1101\/2023.10.06.561062.","DOI":"10.1101\/2023.10.06.561062"},{"key":"B20","doi-asserted-by":"publisher","unstructured":"Vetralla M, Wischhof L, Cadenelli V, Scifo E, Ehninger D, Rizzuto R, Bano D, Stefani DD. TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis (Preprint). bioRxiv 2023.10.10.561661, 2023. doi:10.1101\/2023.10.10.561661.","DOI":"10.1101\/2023.10.10.561661"},{"key":"B21","doi-asserted-by":"publisher","unstructured":"Zhang Y, Reyes L, Sun J, Liu C, Springer D, Noguchi A, Aponte AM, Munasinghe J, Covian R, Murphy E, Glancy B. Loss of TMEM65 causes mitochondrial disease mediated by mitochondrial calcium (Preprint). bioRxiv 2022.08.02.502535, 2023. doi:10.1101\/2022.08.02.502535.","DOI":"10.1101\/2022.08.02.502535"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202254978"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021110476"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201478"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24869-0"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.47.11.1744"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)73805-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature02246"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762732"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.020"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69312"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.032"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0126-8"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature10234"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00704"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature10230"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nature09358"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242993"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.157"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055785"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0331-8"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0330-9"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2309-6"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0333-6"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.050"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4056"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000718"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108486"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00776-w"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.032"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57340-3"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11692-x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.755496"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(74)90077-7"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1976.tb10930.x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147948"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308558110"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-256453"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01435-1"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201311096"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9488-2"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29929"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07755.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9483-7"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212661200"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210784"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708959104"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200975"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006719"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.107"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.041"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4696"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2020.12.011"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035139"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00932.2012"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300410110"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00375.2020"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.03.024"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610491200"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.091"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.11.014"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076578"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.397828"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb13744.x"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.034"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.08.023"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.09.003"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100882R"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.12.019"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0191-7"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121689"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1042\/BST20230012"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.01.005"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1042\/bj1280161"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaz6206"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.2.391"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1042\/bj1760899"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1042\/bj1900095"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1042\/bj2520181"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1042\/bj2630453"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1042\/bj1900107"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.270.4.H1398"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.05.022"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109846"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.002"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134063"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.017"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2868"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2023.05.007"},{"key":"B110","doi-asserted-by":"publisher","unstructured":"Locke TM, Fields R, Gizinski H, Otto GM, Shechner DM, Berg MD, Villen J, Sancak Y, Schweppe D. High-throughput identification of calcium regulated proteins across diverse proteomes (Preprint). bioRxiv 2024.01.18.575273, 2024. doi:10.1101\/2024.01.18.575273.","DOI":"10.1101\/2024.01.18.575273"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002923200"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1021\/bi3015983"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.L120.013975"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30236-4"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510977103"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.027"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.09.009"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.07.004"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)86979-4"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2551-y"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074436"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2622"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.004"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.050"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.015"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602264113"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/nature19774"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.012"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.03.009"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21290"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.005"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.015"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901598R"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6635"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2017.07.009"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27422-1"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-00988-1"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/370621a0"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1700"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.278.2.C423"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00268-20"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16254"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762419"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33220-9"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.03.002"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122686"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw4597"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.04.029"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.11.014"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1113\/JP276636"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2023.05.006"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000137170.41939.d9"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.270.4.H1207"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318562"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055841"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212076"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200301"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112735"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706932"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303062"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16423-1"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.008"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.050"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104708"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2017.12.009"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.11.002"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab324"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97449-3"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029997"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2022.09"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419795112"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0797-z"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15630"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04801"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.06.008"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020204"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00025"},{"key":"B179","first-page":"385","volume":"40","author":"Meyers DE","year":"2013","journal-title":"Tex Heart Inst J"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2004.09.005"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/s0195-668x(02)00387-1"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2008.01.002"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408068200"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.84"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/11396"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.01.001"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn355"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4889(00)00027-6"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3467"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/5089"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-23"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-10031-3"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053755"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab254"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000640117"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048698"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.08.002"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2457"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00124"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101762"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.005"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.045"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiol.00014.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T14:32:59Z","timestamp":1722436379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.00014.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":202,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1152\/physiol.00014.2024"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00014.2024","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-02-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}