{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:31:31Z","timestamp":1792787491806,"version":"4.5.0"},"reference-count":120,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024-159272OB-I00"],"award-info":[{"award-number":["PID2024-159272OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK124308"],"award-info":[{"award-number":["R01DK124308"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Ceriale Family Foundation","award":["Junio Scientist Award"],"award-info":[{"award-number":["Junio Scientist Award"]}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R25CA203650"],"award-info":[{"award-number":["R25CA203650"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Keystone Symposia on Molecular and Cellular Biology Fellows Program","id":[{"id":"https:\/\/ror.org\/02ye8a398","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024-159272OB-I00"],"award-info":[{"award-number":["PID2024-159272OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2022-036653-I"],"award-info":[{"award-number":["RYC2022-036653-I"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003508","name":"Universitat de Val\u00e8ncia","doi-asserted-by":"publisher","award":["UV-INV_AE-3649639"],"award-info":[{"award-number":["UV-INV_AE-3649639"]}],"id":[{"id":"10.13039\/501100003508","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Transdisciplinary Research in Energetics and Cancer Center"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2027,1,1]]},"abstract":"<jats:p>Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway that links nutrient availability to intracellular proteostasis through the targeted turnover of selective proteins. Through this selective control of protein quality, CMA participates in the regulation of metabolic adaptation, cellular homeostasis, and stress responses. CMA is highly responsive to nutritional cues, including caloric restriction (CR), fasting, and changes in macronutrient composition, positioning this pathway as a key mediator of cellular adaptation to metabolic stress. In cancer, CMA displays context-dependent functions that influence tumor metabolism, genomic stability, and survival under adverse microenvironmental conditions. These dual roles suggest that dietary modulation of CMA may shape tumor initiation and progression through effects on cellular proteostasis and metabolic plasticity. In this review, we summarize current knowledge on the molecular mechanisms by which nutritional signals regulate CMA and discuss the physiological implications of nutrition-driven CMA modulation for cancer prevention and therapy.<\/jats:p>","DOI":"10.1152\/physiol.00014.2026","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:41:43Z","timestamp":1784371303000},"page":"000-000","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Modulation of CMA: Implications for Cancer Prevention and Therapy"],"prefix":"10.1152","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7242-8580","authenticated-orcid":false,"given":"Cecilia","family":"Sanchez-Felipe","sequence":"first","affiliation":[{"name":"Universitat de Val\u00e8ncia","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-5072","authenticated-orcid":false,"given":"Esperanza","family":"Arias","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-5450","authenticated-orcid":false,"given":"Julio","family":"Madrigal-Matute","sequence":"additional","affiliation":[{"name":"Universitat de Val\u00e8ncia","place":["Spain"]},{"name":"Parque Cient\u00edfico de la Universitat de Val\u00e8ncia","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14305"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.06.009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507436103"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2026.2626661"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00529-z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.042"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90019-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-016-0031-z"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1210368"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.05.015"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.343"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.09.007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5274.501"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601283"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113036109"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02070-07"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.33.2.437"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.9.5606"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3754"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12310"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1293767"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2016.12.002"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2026.01.003"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02119-3"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3166"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03129-z"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1990670"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121133119"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1848128"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.025"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2063004"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2026.117390"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1136770"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.11.006"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24569"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003182"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04994-x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1075688"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00601-8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21676"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7823"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2409447121"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.044"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600217"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2174\/1568009053332636"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-67591-6_4"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03355-9"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010257"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13677"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.24.4441"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-06-0477"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13616"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3003"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-025-00210-w"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104700"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0719-2"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9846486"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.06.082"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06420-3"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412840111"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa017"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.476"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s13148-011-0044-4"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903542116"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503044"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12765"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.031"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.04.004"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2022.08.002"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.04.002"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.670411"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5473"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.256"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44235"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2317945121"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108863"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.08.021"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3219-11.2011"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.05.030"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-11-1155"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03934-0"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2021.405"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.926789"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2015.1025184"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502456200"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3390\/cimb43020042"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.018"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31869-1"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq2733"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/cells11060920"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071230"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2267415"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.4161\/cc.22027"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.02.059"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16138-3"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2370-6"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1663-5"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ady0415"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01412-9"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00799-6"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8873-0_47"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2675-7_11"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.005"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/srep30340"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1393"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14164-4"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2016.10.009"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01609-x"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000301"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1586255"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13707"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-2161"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.05.013"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306941"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202001031"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiol.00014.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:04:16Z","timestamp":1791997456000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.00014.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1,1]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1,1]]}},"alternative-id":["10.1152\/physiol.00014.2026"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00014.2026","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2027,1,1]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}