{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:19:49Z","timestamp":1792041589676,"version":"4.4.0"},"reference-count":180,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation (NSF)","doi-asserted-by":"publisher","award":["ios1446310"],"award-info":[{"award-number":["ios1446310"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    The chemical versatility of sulfur and its abundance in the prebiotic Earth as reduced sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) implicate this molecule in the origin of life 3.8 billion years ago and also as a major source of energy in the first seven-eighths of evolution. The tremendous increase in ambient oxygen \u223c600 million years ago brought an end to H\n                    <jats:sub>2<\/jats:sub>\n                    S as an energy source, and H\n                    <jats:sub>2<\/jats:sub>\n                    S-dependent animals either became extinct, retreated to isolated sulfide niches, or adapted. The first 3 billion years of molecular tinkering were not lost, however, and much of this biochemical armamentarium easily adapted to an oxic environment where it contributes to metabolism and signaling even in humans. This review examines the role of H\n                    <jats:sub>2<\/jats:sub>\n                    S in evolution and the evolution of H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism and signaling.\n                  <\/jats:p>","DOI":"10.1152\/physiol.00024.2015","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T22:29:48Z","timestamp":1450304988000},"page":"60-72","source":"Crossref","is-referenced-by-count":231,"title":["The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and Signaling"],"prefix":"10.1152","volume":"31","author":[{"given":"Kenneth R.","family":"Olson","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, South Bend, South Bend, Indiana; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl D.","family":"Straub","sequence":"additional","affiliation":[{"name":"Central Arkansas Veteran's Healthcare System and University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(92)90015-F"},{"key":"B2","first-page":"519","volume":"160","author":"Bagarinao T","year":"1990","journal-title":"J Comp Physiol A"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.08.037"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsl.2005.06.062"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9269-1_10"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)01202-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503674102"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3678"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/ast.2007.0187"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.10.003"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01480.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn246"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06541.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2014-0051"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808026200"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.earth.32.101802.120225"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-008-9166-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.12.009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature12426"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(72)90382-6"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2006.12.018"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004929"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.10.016"},{"key":"B25","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1242\/jeb.202.14.1953","volume":"202","author":"Doeller JE","year":"1999","journal-title":"J Exp Biol"},{"key":"B26","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1242\/jeb.204.21.3755","volume":"204","author":"Doeller JE","year":"2001","journal-title":"J Exp Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200250371"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature04546"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00105.2011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.09.015"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-004-0718-9"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115634109"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00657-8"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature10460"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12932-014-0012-y"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7407com"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00116"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5041"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.04.002"},{"key":"B40","unstructured":"Griesbeck C, Hauska G, Sch\u00fcltz M. 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