{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:34:13Z","timestamp":1762814053043,"version":"build-2065373602"},"reference-count":0,"publisher":"American Physiological Society","funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["Project 101073316\/RETORNA\/HORIZON-MSCA-2021-DN-01"],"award-info":[{"award-number":["Project 101073316\/RETORNA\/HORIZON-MSCA-2021-DN-01"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["H93C22000660006-MNESYS"],"award-info":[{"award-number":["H93C22000660006-MNESYS"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scuola Superiore Meridionale","award":["GEM_04_2022"],"award-info":[{"award-number":["GEM_04_2022"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"abstract":"<jats:p>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. Several studies have highlighted their role as key regulators of different physiological processes that underly retinal homeostasis. Recent evidence suggests that they play a role not only at the intracellular level but also extracellularly, participating in cell-cell crosstalk by being transported via extracellular vesicles (EVs). Moreover, changes in miRNA expression levels have been associated with different forms of retinal diseases, such as Inherited Retinal Diseases (IRDs). IRDs are a group of genetic disorders characterized by photoreceptor cell death and retinal degeneration. Notably, miRNAs can simultaneously regulate multiple molecular pathways associated with disease initiation and progression. Finally, modulation of miRNAs through upregulation or downregulation has shown beneficial effects in different IRD mouse models. Here, we provide a comprehensive overview of retinal miRNA expression profiles in both healthy and IRD conditions and explore their potential as therapeutic targets for clinical applications.<\/jats:p>","DOI":"10.1152\/physiol.00035.2025","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:31:41Z","timestamp":1762813901000},"update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of miRNAs in retinal physiology and in Inherited Retinal Disorders"],"prefix":"10.1152","author":[{"given":"Paola","family":"Brandi","sequence":"first","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM)"},{"name":"Genomics and Experimental Medicine Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM)"},{"name":"University of Campania \"Luigi Vanvitelli\""}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-8833","authenticated-orcid":false,"given":"Sandro","family":"Banfi","sequence":"additional","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM)"},{"name":"University of Campania \"Luigi Vanvitelli\""}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiol.00035.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:31:41Z","timestamp":1762813901000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.00035.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"alternative-id":["10.1152\/physiol.00035.2025"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00035.2025","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"physiol.00035.2025"}}