{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:22:08Z","timestamp":1773422528294,"version":"3.50.1"},"reference-count":26,"publisher":"American Physiological Society","issue":"7","funder":[{"name":"\u00c5ke Wiberg foundation"},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden (Swedish Heart-Lung Foundation)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning (Swedish Society for Medical Research)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Marcus Borgstr\u00f6m foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:p> Genetic background of different mouse strains determines their susceptibility to disease. We have previously shown that Balb\/CJ and C57BL\/6J mice develop cardiac hypertrophy to the same degree when treated with a combination of angiotensin II and high-salt diet (ANG II+Salt), but only Balb\/CJ show impaired cardiac function associated with edema development and substantial mortality. We hypothesized that the different response to ANG II+Salt is due to the different genetic backgrounds of Balb\/CJ and C57BL\/6J. To address this we performed quantitative trait locus (QTL) mapping of second filial generation (F2) of mice derived from a backcross between Balb\/CJ and first filial generation (F1) of mice. Cardiac function was measured with echocardiography, glomerular filtration rate using FITC-inulin clearance, fluid and electrolyte balance in metabolic cages, and blood pressure with tail-cuff at baseline and on the fourth day of treatment with ANG II+Salt. A total of nine QTLs were found to be linked to different phenotypes in ANG II+Salt-treated F2 mice. A QTL on chromosome 3 was linked to cardiac output, and a QTL on chromosome 12 was linked to isovolumic relaxation time. QTLs on chromosome 2 and 3 were linked to urine excretion and sodium excretion. Eight genes located at the different QTLs contained coding nonsynonymous SNPs published in the mouse genome database that differ between Balb\/CJ and C57BL\/6J. In conclusion, ANG II+Salt-induced acute decompensation in Balb\/CJ is genetically linked to several QTLs, indicating a multifaceted phenotype. The present study identified potential candidate genes that may represent important pathways in acute decompensated heart failure. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00017.2019","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T13:44:22Z","timestamp":1558705462000},"page":"279-289","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative trait loci associated with angiotensin II and high-salt diet induced acute decompensated heart failure in Balb\/CJ mice"],"prefix":"10.1152","volume":"51","author":[{"given":"Mediha","family":"Becirovic-Agic","sequence":"first","affiliation":[{"name":"Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-9488","authenticated-orcid":false,"given":"Sofia","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-1099","authenticated-orcid":false,"given":"Michael","family":"Hultstr\u00f6m","sequence":"additional","affiliation":[{"name":"Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"},{"name":"Anesthesia and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051620"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00098-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00373.2018"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00043-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1994"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg112"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.268"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1127"},{"key":"B9","first-page":"S115","volume":"19","author":"Frangiosa A","year":"2006","journal-title":"J Nephrol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00284.2005"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2626"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00483.2018"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.110.115014"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg333"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052948"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4059"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.067"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.08.008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00502.2011"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00324.2003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135931"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63305-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.07.010"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1385\/CT:3:2:153"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/925350"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00017.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T17:37:57Z","timestamp":1569346677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00017.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,1]]}},"alternative-id":["10.1152\/physiolgenomics.00017.2019"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00017.2019","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]}}}