{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:15:27Z","timestamp":1772205327980,"version":"3.50.1"},"reference-count":17,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p> It has been reported that SEMA3B-AS1 is a tumor-suppressive lncRNA in gastric cardia adenocarcinoma. We explored the possible involvement of SEMA3B-AS1 in hepatocellular carcinoma (HCC). We found that SEMA3B-AS1 was downregulated in HCC tissues compared with noncancer tissues and was not affected by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In addition, SEMA3B-AS1 expression was not affect by cancer development, and low SEMA3B-AS1 levels were closely correlated with poor survival. SEMA3B-AS1 in HCC tissues was inversely correlated with microRNA (miR)-718 and positively correlated with PTEN. In HCC cells, SEMA3B-AS1 overexpression resulted in upregulated, while miR-718 overexpression resulted in downregulated phosphatase and tensin homolog (PTEN) expression. In addition, miR-718 overexpression attenuated the effects of SEMA3B-AS1 overexpression. SEMA3B-AS1 and PTEN overexpression resulted in a reduced proliferation rate of HCC cells, while miR-718 overexpression resulted in an increased rate. In addition, miR-718 overexpression attenuated the effects of SEMA3B-AS1 overexpression. Therefore, miR-718 may mediate the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00019.2019","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T14:54:32Z","timestamp":1561733672000},"page":"500-505","source":"Crossref","is-referenced-by-count":23,"title":["MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells"],"prefix":"10.1152","volume":"51","author":[{"given":"Yuchuan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3449"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i12.1632"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S61146"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.06.016"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.11.008"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84421"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-00924-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.749325"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.184"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.025"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.035"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.7805"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26369"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1645"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.061"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00019.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T15:00:40Z","timestamp":1569423640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00019.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,1]]}},"alternative-id":["10.1152\/physiolgenomics.00019.2019"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00019.2019","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}