{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:16:53Z","timestamp":1776446213739,"version":"3.51.2"},"reference-count":63,"publisher":"American Physiological Society","issue":"9","funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme (EC Seventh Framework Programme)","doi-asserted-by":"publisher","award":["311794"],"award-info":[{"award-number":["311794"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:p>Feed efficiency (FE) is a measure of the rate between feed intake and body weight gain and is subject to constant progress in pigs, based on extensive performance tests and analyses of physiological parameters. However, endocrine regulatory circuits that comprise the sensation and perception of intrinsic requirements and appropriate systemic responses have not yet been fully elucidated. It is hypothesized that the gut-brain axis, which is a network of hierarchical anterior regulatory tissues, contributes largely to variations in FE. Therefore, full-sib pigs with extreme residual feed intake values were assigned to experimental groups of high and low FE. Relevant hormones, minerals, and metabolites including fatty acid profiles were analyzed in serum to assess postprandial conditions. Transcriptome profiles were deduced from intestinal (duodenum, jejunum, ileum) and neuroendocrine tissues (hypothalamus). Serum analyses of feed-efficient animals showed an increased content of the incretin GIP, calcium, magnesium, \u03b2-hydroxybutyric acid, and fat compared with low-FE pigs. Complementary expression profiles in intestinal tissues indicate a modulated permeability and host-microbe interaction in FE-divergent pigs. Transcriptomic analyses of the hypothalamus showed that differences between the FE groups in appetite and satiety regulation are less pronounced. However, hypothalamic abundance of transcripts like ADCY7, LHCGR, and SLC2A7 and molecular signatures in local and systemic tissue sites indicate that increased allocation and circulation of energy equivalents, minerals, and hormones are promoted in feed-efficient animals. Overall, patterns of gastrointestinal hormones and gene expression profiles identified host-microbiota interaction, intestinal permeability, feed intake regulation, and energy expenditure as potential mechanisms affecting FE in pigs.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00021.2018","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T19:45:02Z","timestamp":1529091902000},"page":"726-734","source":"Crossref","is-referenced-by-count":14,"title":["Feed-efficient pigs exhibit molecular patterns allowing a timely circulation of hormones and nutrients"],"prefix":"10.1152","volume":"50","author":[{"given":"Henry","family":"Reyer","sequence":"first","affiliation":[{"name":"Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Oster","sequence":"additional","affiliation":[{"name":"Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Magowan","sequence":"additional","affiliation":[{"name":"Agri-Food and Biosciences Institute, Hillsborough, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Mur\u00e1ni","sequence":"additional","affiliation":[{"name":"Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga","family":"Sauerwein","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Physiology and Hygiene, University of Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Dannenberger","sequence":"additional","affiliation":[{"name":"Institute of Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Kuhla","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Physiology \u201cOskar Kellner\u201d, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[{"name":"Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-6790","authenticated-orcid":false,"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[{"name":"Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"},{"name":"Faculty of Agricultural and Environmental Sciences, University Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.08.005"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.5709"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2527\/2003.811167x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp101"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30227"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2016.11.015"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-8640"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-15-27"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2015.04.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti525"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00012-X"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4797"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-7059"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-10-90"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7716"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.11.039"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.1.R107"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000705"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2015-9692"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2170"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12850"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1995.tb00757.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2527\/jas.53855"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skx074"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173482"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90899.2008"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn647"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115360"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731115000932"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2010.04.005"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5226"},{"key":"B33","first-page":"73","volume":"51","author":"Lefaucher L","year":"2008","journal-title":"Arch Tierzucht"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2010-3493"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00119.2003"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/age.12440"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00632.2009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2527\/2001.7982075x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5906"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-6053"},{"key":"B41","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/S0021-9258(19)77135-X","volume":"245","author":"Marsh JM","year":"1970","journal-title":"J Biol Chem"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00380-17"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174917"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-7646"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3133"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nature05484"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1563"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.116975"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-015-0031-2"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3181\/0709-MR-262"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081674"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-017-1325-1"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2016.1172034"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12084"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.livprodsci.2003.08.001"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00536.2003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.16.0200"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1201\/9781420009156"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.206.1.243"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148145"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731116000847"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00021.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T20:46:34Z","timestamp":1661460394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00021.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,1]]}},"alternative-id":["10.1152\/physiolgenomics.00021.2018"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00021.2018","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}