{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:10:33Z","timestamp":1785337833009,"version":"3.55.0"},"reference-count":68,"publisher":"American Physiological Society","issue":"8","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI128729"],"award-info":[{"award-number":["R01AI128729"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI169530"],"award-info":[{"award-number":["R01AI169530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minnesota Agriculture Experiment Station","award":["AES0016134"],"award-info":[{"award-number":["AES0016134"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>Exposure of airway epithelia to environmental allergens or nanoparticles invokes a novel genome-protective physiological response to oxidative stress. Fragments of double-stranded genomic DNA released into the airway lumen originate from repetitive, transcriptionally active, and fragile sites within the genome. Exporting DNA with high repetitive content potentially aids cell survival through the preservation of genome integrity and fidelity during the repair process.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00029.2026","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:31:27Z","timestamp":1783978287000},"page":"382-393","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA"],"prefix":"10.1152","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-8465","authenticated-orcid":false,"given":"Kayla","family":"Law","sequence":"first","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotesawee","family":"Srisomboon","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Iijima","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-9658","authenticated-orcid":false,"given":"Christopher","family":"Faulk","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-2936","authenticated-orcid":false,"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-5451","authenticated-orcid":false,"given":"Scott M.","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9050582"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108333"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169071"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-017-0228-y"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/all.13158"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.09.034"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3703"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.045"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"B10","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, 2024. https:\/\/www.R-project.org."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx183"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp328"},{"key":"B13","unstructured":"Wickham H, Francois R, Henry L, Muller K, Vaughan D. dplyr: A Grammar of Data Manipulation, Version 1.1.4.9000. 2025. https:\/\/github.com\/tiddyverse\/dplyr."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003118"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq8191"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj6987"},{"key":"B18","unstructured":"Smit A, Hubley R, Green P. RepeatMasker Open-4.0. ISB, 2013. https:\/\/www.repeatmasker.org\/."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae974"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr017"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-020-00230-y"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(87)90232-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4178"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0845-21.2021"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2020.10.006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155392"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507350103"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2174\/1566524011313040007"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00085-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300770200"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1379-8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1279"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0412-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks056"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1101\/gr.5335506"},{"key":"B36","first-page":"4054","volume":"62","author":"Turner BC","year":"2002","journal-title":"Cancer Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.05.019"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.013"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000499886"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25887"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107061"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1719907115"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13674-5"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.039"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1753-6"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms130911974"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3865-03.2004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4740-04.2005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/ng.841"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-6-17"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00937"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.189"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1951-05.2005"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilx013"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.12.2775"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112590"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900502"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.012"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000155"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw261"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212599"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2014.999192"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410746200"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2769-8"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-024-03327-2"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/nature11082"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015634118"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06545-y"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00029.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:39:57Z","timestamp":1785335997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00029.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,1]]}},"alternative-id":["10.1152\/physiolgenomics.00029.2026"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00029.2026","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}