{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:33:45Z","timestamp":1783546425832,"version":"3.55.0"},"reference-count":72,"publisher":"American Physiological Society","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020374","name":"Ministry of AYUSH, Government of India","doi-asserted-by":"publisher","award":["GAP0183"],"award-info":[{"award-number":["GAP0183"]}],"id":[{"id":"10.13039\/100020374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p> Our study delves into the multifaceted response to hypoxia, integrating gene expression and hematological, biochemical, and physiological assessments. Hypoxia, crucial in both physiology and pathology, prompts varied responses, necessitating a thorough systemic understanding. Examining healthy subjects exposed to graded normobaric hypoxia, we observed significant shifts in heart rate, oxygen saturation, and heart rate variability. Moreover, genomic analysis unveiled distinct gene signatures associated with physiological parameters, offering insights into molecular perturbations and adaptations to oxygen deprivation. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00056.2024","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T08:10:31Z","timestamp":1735027831000},"page":"49-64","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Physiological, biochemical, and genome-wide expression patterns during graded normobaric hypoxia in healthy individuals"],"prefix":"10.1152","volume":"57","author":[{"given":"Ritu","family":"Rani","sequence":"first","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics, Council of Scientific and Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"CSIR\u2019s Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics), CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"},{"name":"Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintu","family":"Kutum","sequence":"additional","affiliation":[{"name":"CSIR\u2019s Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics), CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"},{"name":"Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3784-255X","authenticated-orcid":false,"given":"Deep Shikha","family":"Punera","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics, Council of Scientific and Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"CSIR\u2019s Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics), CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"},{"name":"Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand Prakash","family":"Yadav","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics, Council of Scientific and Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"Vallabhbhai Patel Chest Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Bansal","sequence":"additional","affiliation":[{"name":"Vallabhbhai Patel Chest Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-4400","authenticated-orcid":false,"given":"Bhavana","family":"Prasher","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics, Council of Scientific and Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"CSIR\u2019s Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics), CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"},{"name":"Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.13-256-RA"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104720"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.04.009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01374-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100069"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(91)90054-m"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200311000-00002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650796"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/JP275696"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.04.003"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1366"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1145503"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/978-81-322-1928-6_8"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2013.1143"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2014.1052.1057"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s11332-015-0235-z"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2012.02407.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3357\/asem.2390.2009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12310"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep26468"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst089"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-015-0268-y"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0932-2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2009.1060"},{"key":"B25","first-page":"1182","volume":"69","author":"Roach RC","year":"1998","journal-title":"Aviat Space Environ Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14090"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz101"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/age.12740"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evy264"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-015-1064-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6499"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.559074"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icj005"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050708"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2004.10321"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2010005000082"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00258"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2014.6944639"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-1838(96)00112-9"},{"key":"B42","first-page":"1015","volume":"77","author":"Iwasaki K","year":"2006","journal-title":"Aviat Space Environ Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2017.0164"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp427"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0878-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.5935\/2359-4802.20170035"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-73"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2016.1207708"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12381"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2023.2238923"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297553"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77724-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934316"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00752"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00697"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bat074"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.18.5197"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.068"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0211"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061185"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2016.0012"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-211"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.08.006"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.05.004"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06188.x"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(02)01370-9"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-291x(03)00814-3"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.06.009"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1644"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005035"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.03.004"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.106"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00056.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T20:37:35Z","timestamp":1743712655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00056.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"alternative-id":["10.1152\/physiolgenomics.00056.2024"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00056.2024","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"assertion":[{"value":"2024-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}