{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:07:56Z","timestamp":1780970876028,"version":"3.54.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011092"],"award-info":[{"award-number":["P51OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004060","name":"Preeclampsia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p> Preeclampsia is a life-threatening hypertensive disorder, affecting 2%\u20135% of pregnancies, that remains poorly understood. This study analyzed DNA methylation from buccal swabs from mothers who experienced early and late-stage preeclampsia and those with uncomplicated pregnancies, along with their children. Differentially methylated regions were found near and within genes crucial for placental function, embryonic development, and inflammation. Many of these genes are expressed in preeclampsia-related tissues, offering hope for future biomarker development for this condition. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00058.2023","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T09:48:27Z","timestamp":1704707307000},"page":"276-282","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their children"],"prefix":"10.1152","volume":"56","author":[{"given":"Cora E.","family":"Layman","sequence":"first","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1921","authenticated-orcid":false,"given":"Brett A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Nevonen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Okhovat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Rincon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Valent","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-107X","authenticated-orcid":false,"given":"Lucia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"},{"name":"Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States"},{"name":"Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, United States"},{"name":"Division of Genetics, Oregon National Primate Research Center, Beaverton, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-4785","authenticated-orcid":false,"given":"Kent L.","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States"},{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, United States"},{"name":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a45b25"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62310-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.12.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1753"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.01.115"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2381"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.08.070"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1542"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190070"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2011.649931"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00206"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226201"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000366386"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134119"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr167"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-10-r87"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0128-8"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.190"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6445.1"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02872"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20190033"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00076.2017"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77241"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.035"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05126-8"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6718"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03941-4"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu145"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-011-0057-0"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.1.94"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0184"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00058.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T14:17:00Z","timestamp":1707920220000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00058.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["10.1152\/physiolgenomics.00058.2023"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00058.2023","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}