{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:36:02Z","timestamp":1790264162670,"version":"4.1.0"},"reference-count":45,"publisher":"American Physiological Society","issue":"9","funder":[{"name":"University of Toledo College of Medicine and Life Sciences","award":["Dean's Postdoctoral to Faculty Fellowship"],"award-info":[{"award-number":["Dean's Postdoctoral to Faculty Fellowship"]}]},{"name":"NIDA Center of Excellence in Omics, Systems Genetics, and the Addictome","award":["P30 Core Center Pilot Grant"],"award-info":[{"award-number":["P30 Core Center Pilot Grant"]}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL143082"],"award-info":[{"award-number":["HL143082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p> Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common types of cardiomyopathies leading to heart failure. Accurate diagnostic classification of different types of cardiomyopathies is critical for precision medicine in clinical practice. In this study, we hypothesized that machine learning (ML) can be used as a novel diagnostic approach to analyze cardiac transcriptomic data for classifying clinical cardiomyopathies. RNA-Seq data of human left ventricle tissues were collected from 41 DCM patients, 47 ICM patients, and 49 nonfailure controls (NF) and tested using five ML algorithms: support vector machine with radial kernel (svmRadial), neural networks with principal component analysis (pcaNNet), decision tree (DT), elastic net (ENet), and random forest (RF). Initial ML classifications achieved ~93% accuracy (svmRadial) for NF vs. DCM, ~82% accuracy (RF) for NF vs. ICM, and ~80% accuracy (ENet and svmRadial) for DCM vs. ICM. Next, 50 highly contributing genes (HCGs) for classifying NF and DCM, 68 HCGs for classifying NF and ICM, and 59 HCGs for classifying DCM and ICM were selected for retraining ML models. Impressively, the retrained models achieved ~90% accuracy (RF) for NF vs. DCM, ~90% accuracy (pcaNNet) for NF vs. ICM, and ~85% accuracy (pcaNNet and RF) for DCM vs. ICM. Pathway analyses further confirmed the involvement of those selected HCGs in cardiac dysfunctions such as cardiomyopathies, cardiac hypertrophies, and fibrosis. Overall, our study demonstrates the promising potential of using artificial intelligence via ML modeling as a novel approach to achieve a greater level of precision in diagnosing different types of cardiomyopathies. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00063.2020","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T19:53:55Z","timestamp":1596484435000},"page":"391-400","source":"Crossref","is-referenced-by-count":33,"title":["Machine learning-based classification and diagnosis of clinical cardiomyopathies"],"prefix":"10.1152","volume":"52","author":[{"given":"Ahmad","family":"Alimadadi","sequence":"first","affiliation":[{"name":"Bioinformatics & Artificial Intelligence Laboratory, Center for Hypertension and Precision Medicine, Program in Physiological Genomics, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"},{"name":"Bioinformatics Program, University of Toledo College of 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