{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:57:02Z","timestamp":1787846222933,"version":"build-2784847793"},"reference-count":84,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100009317","name":"Faculty of Health and Medical Sciences, University of Western Australia","doi-asserted-by":"publisher","award":["Australian Government Research Training Program scholarship"],"award-info":[{"award-number":["Australian Government Research Training Program scholarship"]}],"id":[{"id":"10.13039\/501100009317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p> The study found discriminative microorganisms differentiating patients with acute coronary syndrome (ACS) from healthy controls. In addition, reduced levels of certain bacterial metabolites and elevated sCD14 and sCD163 were observed in patients with ACS compared with healthy controls. Furthermore, modified small molecule metabolomic and lipidomic signatures were found in both patient groups. Although it is not known whether these differences in profiles are associated with disease development and\/or progression, the findings provide exciting options for potential new disease-related mechanism(s) and associated therapeutic target(s). <\/jats:p>","DOI":"10.1152\/physiolgenomics.00072.2023","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:47:41Z","timestamp":1696848461000},"page":"48-64","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome"],"prefix":"10.1152","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-0875","authenticated-orcid":false,"given":"Adilah F.","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Caparr\u00f3s-Martin","sequence":"additional","affiliation":[{"name":"Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Gray","sequence":"additional","affiliation":[{"name":"Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-0462","authenticated-orcid":false,"given":"Samantha","family":"Lodge","sequence":"additional","affiliation":[{"name":"Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-2572","authenticated-orcid":false,"given":"Julien","family":"Wist","sequence":"additional","affiliation":[{"name":"Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Department of Microbiology, PathWest Laboratory Medicine, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal","family":"O\u2019Gara","sequence":"additional","affiliation":[{"name":"Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"BIOMERIT Research Centre, School of Microbiology, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0717-740X","authenticated-orcid":false,"given":"Girish","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Department of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-437X","authenticated-orcid":false,"given":"Natalie C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Dobney Hypertension Centre, Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.11.008"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2015.042"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/HCQ.0000000000000112"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.09.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1302154"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00081.2016"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00376.2019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6458094"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00900-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309715"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3145"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2018.03.046"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18756-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(82)80339-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0451"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313234"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237579"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11100685"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.616081"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051126"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.572504"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks808"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17041-7"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28521-8"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00519"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11070467"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00682"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0312-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.949563"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248508"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.120"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.06.024"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180190"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041542"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101706"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001043"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/949672"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02144-y"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.11.026"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.12.16"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107100"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311023"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw582"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/srep26745"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002816"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.264853"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.11.006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2021.01.020"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.011"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-115"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00032"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117169"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200310000-00014"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01570-4"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300421"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.05.011"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2019.1614213"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/npjgenmed.2016.38"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13291-6"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099598"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0381-7_67"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(97)00354-8"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(99)00781-x"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124079"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13668-3"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/820695"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab562"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041215"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i13.1246"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.013116"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-802"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00876"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-7-200904070-00007"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz235"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-005-0065-6"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142676"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P081281"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.12.005"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33116-4"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.09.016"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00737-2"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00072.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T14:42:10Z","timestamp":1702996930000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00072.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"alternative-id":["10.1152\/physiolgenomics.00072.2023"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00072.2023","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]},"assertion":[{"value":"2023-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}