{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:33:53Z","timestamp":1769661233898,"version":"3.49.0"},"reference-count":108,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"NIH T32","award":["AG020494"],"award-info":[{"award-number":["AG020494"]}]},{"DOI":"10.13039\/100017787","name":"UNTHSC","doi-asserted-by":"crossref","award":["Start-up Funds"],"award-info":[{"award-number":["Start-up Funds"]}],"id":[{"id":"10.13039\/100017787","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>Adult IUGR male rodent offspring exposed to placental ischemia in utero have elevated mean arterial blood pressure with increased brain miRNA let-7d-3p expression, mitochondrial dysfunction, and oxidative stress, while adult IUGR females do not. Moreover, our results suggest that brain epigenetic changes may contribute to mitochondrial dysfunction and oxidative stress, eventually leading to hypertension. In conclusion, lifetime health begins in utero, and patients and healthcare providers should be aware of the consequences that prenatal stressors have on long-term health.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00086.2025","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:19:58Z","timestamp":1766020798000},"page":"73-88","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rodents exposed to placental ischemia in utero display sex differences in brain miRNA expression, mitochondrial function, and blood pressure in adulthood"],"prefix":"10.1152","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-9799","authenticated-orcid":false,"given":"Savanna Leigh","family":"Smith","sequence":"first","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8108-8051","authenticated-orcid":false,"given":"Angie","family":"Castillo","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonna","family":"Smith","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Jones","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-1993","authenticated-orcid":false,"given":"Kumudu","family":"Subasinghe","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-0286","authenticated-orcid":false,"given":"Robert","family":"Barber","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole R.","family":"Phillips","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5947-7746","authenticated-orcid":false,"given":"Ahfiya","family":"Howard","sequence":"additional","affiliation":[{"name":"East Texas A&M University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-9389","authenticated-orcid":false,"given":"Allison","family":"Burkes","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlan","family":"Jones","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-4375","authenticated-orcid":false,"suffix":"Jr.","given":"Mark W.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2025.2454597"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2020.10.005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00218.2017"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000914"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060953"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.03.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.01.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.6.10.1367"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.83"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180712114531"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26044"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S40070"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1159\/000353633"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190070"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006323"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2023.100688"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00006.2017"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.108.125567"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112891"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.108.116905"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111824"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1209890"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1530\/joe-19-0009"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020157"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1257\/jep.25.3.153"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/genes5040865"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199805000-00001"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00280.2009"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00322.2002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1042\/cs20210524"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jp285496"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.612888"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00495.2014"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10782"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00242.2010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.07.008"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2023-004"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0062-21.2021"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050963"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2442"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1113\/jp271402"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00117.2012"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.09969"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00056.2024"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/01.Hyp.0000053448.95913.3d"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00396-x"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.11.004"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171118"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10681"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2020.1793999"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11290"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00152.2020"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001628"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s12867-019-0120-4"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140970"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1791"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.009"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15518"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174422000575"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-0969-0"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1113\/JP275428"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00234.2020"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.09.010"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.717550"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00178"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-022-00611-4"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.170407"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20783"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/ani12162102"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.06.006"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051007"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.2174\/1389203720666190124165243"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab251"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1179288"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-124768"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13470-5"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.838737"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0372-6"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-20"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0889-4"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103637"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052313"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103145"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2020.10.004"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(88)90051-2"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131310"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064545"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208784"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031386"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1444543"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02322-8"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11010078"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2025.149448"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-3782(97)00124-2"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-2993(98)80009-2"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_47_17"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2020.10.002"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13588"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roaf059"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09698-3"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001763"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0687"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00086.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T18:39:46Z","timestamp":1769452786000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00086.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/physiolgenomics.00086.2025"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00086.2025","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}