{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:08:17Z","timestamp":1793261297860,"version":"4.5.0"},"reference-count":20,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2001,12,21]]},"abstract":"<jats:p>The Oak Ridge polycystic kidney ( orpk) mutant mouse model resulted from a transgene insertion into the Tg737 gene and exhibits a pleiotropic syndrome with lesions in the kidney, liver, and pancreas. We found marked differences in the phenotypic expression of the orpk mutation when bred on different genetic backgrounds. In the FVB\/N background, the phenotype is very severe for kidney, pancreas, and liver lesions. To evaluate better how genetic background might influence the expressivity of the orpk phenotype, we bred the transgene into the C3HeB\/FeJLe (C3H) genetic background. We performed a genome-wide scan using backcross and intercross populations with more than 150 markers to map the chromosomal location of the modifier genes that differ in the FVB\/N and C3H genetic backgrounds that affect the severity of kidney disease in the orpk mouse. Low-resolution interval mapping was performed using the Map Manager QTb program, with the interval explaining a significant portion of the variance being the distal end of chromosome 4.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00089.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:55:56Z","timestamp":1425416156000},"page":"127-134","source":"Crossref","is-referenced-by-count":15,"title":["Phenotypic variations of<i>orpk<\/i>mutation and chromosomal localization of modifiers influencing kidney phenotype"],"prefix":"10.1152","volume":"7","author":[{"given":"CARLA","family":"SOMMARDAHL","sequence":"first","affiliation":[{"name":"Department of Pathology and Department of Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37901-1071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARILYN","family":"COTTRELL","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37901-1071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. ERBY","family":"WILKINSON","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37901-1071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD P.","family":"WOYCHIK","sequence":"additional","affiliation":[{"name":"Lynx Therapeutics, Hayward, California 94545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DABNEY K.","family":"JOHNSON","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)47448-9"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80921-8"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.423"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(95)80088-4"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.12-tac-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00859625"},{"key":"R8","unstructured":"Kuida S and Beier DR.Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease.Genome Res10: 49\u201354, 2000."},{"key":"R8A","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091226"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-179"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900997"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1126\/science.8191288"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, and Woychik RP.The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.Development127: 2347\u20132355, 2000.","DOI":"10.1242\/dev.127.11.2347"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900706"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900485"},{"key":"R16","unstructured":"Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N, Woychik RP, and Wilkinson JE.Oval cell proliferation associated with the murine insertional mutationTgN737Rpw.Am J Pathol149: 1919\u20131930, 1996."},{"key":"R17","unstructured":"Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N, Woychik RP, and Wilkinson JE.Isolation and characterization of liver epithelial cell lines from wild-type and mutantTgN737Rpwmice.Am J Pathol150: 1189\u20131197, 1997."},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Takahashi H, Calvet JP, Dittemore-Hoover D, Yoshida K, Grantham JJ, Gattone VH II.A hereditary model of slowly progressive polycystic kidney disease in the mouse.J Am Soc Nephrol1: 980\u2013989, 1991.","DOI":"10.1681\/ASN.V17980"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119724"},{"key":"R20","unstructured":"Woo DDL, Tran T, and Kurtz I.Genetic identification of two major modifying loci that control the progression of polycystic kidney disease in the cpk mice (Abstract).J Am Soc Nephrol7: 1609, 1996."}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00089.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T09:50:30Z","timestamp":1651398630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00089.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,21]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,12,21]]}},"alternative-id":["10.1152\/physiolgenomics.00089.2001"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00089.2001","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,21]]}}}