{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T21:51:54Z","timestamp":1715723514343},"reference-count":5,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"Established Clinical Investigator of the Netherlands Heart Foundation","award":["2001 D 032"],"award-info":[{"award-number":["2001 D 032"]}]},{"name":"the seventh framework program of the European commission","award":["223004"],"award-info":[{"award-number":["223004"]}]},{"name":"the Netherlands Genomics Initiative","award":["050-060-810"],"award-info":[{"award-number":["050-060-810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p> Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer\u2019s disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 ( n = 73) were assessed in 5,244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age 75.3 yr). Linear regression, adjusted for age, sex, country, and use of pravastatin, was used to assess the association between the SNPs and cognitive function. All 73 SNPs within the genomic region of the CR1 gene on chromosome 1 were extracted. Eighteen were independent, according to a relatively stringent R<jats:sup>2<\/jats:sup> threshold of &gt;0.8 with LDlink. Twelve of the 18 investigated CR1 SNPs were significantly associated with a decline in cognitive function (all P &lt; 0.05). These data indicate that genetic variation within the CR1 gene is associated not only with Alzheimer\u2019s disease, but also with general cognitive function during late life. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00102.2017","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T17:30:23Z","timestamp":1512581423000},"page":"102-103","source":"Crossref","is-referenced-by-count":3,"title":["Association of complement receptor 1 gene polymorphisms with cognitive function"],"prefix":"10.1152","volume":"50","author":[{"given":"L. E.","family":"Zijlstra","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Mooijaart","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Stott","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, University of Glasgow, Glasgow, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Castro Cabezas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Trompet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05668.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22277"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149792"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00533-0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.12.017"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00102.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T14:57:23Z","timestamp":1567954643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00102.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,1]]}},"alternative-id":["10.1152\/physiolgenomics.00102.2017"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00102.2017","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}